中西医治疗化疗药物诱导周围神经病变临床研究进展  

Research Progress on Chinese and Western Medicine in the Clinical Treatment of Chemotherapy-induced Peripheral Neuropathy

作　　者：于源 陈丽娟 孙金芳 YU Yuan;CHEN Lijuan;SUN Jinfang(the First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Ji′nan 250355,China;Cancer Center of Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser Hospital),Qingdao 266033,China;Hematology Department of West Branch of Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser Hospital),Qingdao 266002,China)

机构地区：[1]山东中医药大学第一临床医学院,济南250355 [2]青岛市中医医院〔市海慈医院〕肿瘤中心,青岛266033 [3]青岛市中医医院(市海慈医院)西院区血液科,青岛266002

出　　处：《世界中医药》2024年第9期1348-1354,共7页World Chinese Medicine

基　　金：国家自然科学基金项目(81973677);2021年度山东省中医药科技项目(2021M111);2020年度山东省中医药科技项目(2020Z31);2020年度山东省中医药科技项目(2020Q075);海藻活性物质国家重点实验室开放基金项目(SKL-BASS1805);青岛市2021年度医药卫生科研计划项目(2021-WJZD034)。

摘　　要：奥沙利铂及紫杉醇等化疗药物因具有无交叉耐药性、抗肿瘤活性谱广等优点成为临床抗肿瘤常用药。化疗药物诱导的周围神经病变作为影响疗效及患者依从性的主要不良反应,近年来也逐渐成为学界研究热点议题之一。中西医在化疗诱导的周围神经病变的治疗方面各有所长,西医从局部微环境作用入手缓解麻木疼痛等神经反应,中医则着眼于患者整体,重在补养全身气血以荣其筋脉。中西医治疗理论及方法各具特色。Oxaliplatin and paclitaxel,among other chemotherapy drugs,are commonly used in clinical oncology due to their advantages such as non-cross-resistance and broad spectrum of anti-tumor activity.Chemotherapy-induced peripheral neuropathy(CIPN),as a major adverse reaction that affects treatment efficacy and patient compliance,has gradually become one of the hot topics in research in recent years.Both Chinese medicine and western medicine have their strengths in the treatment of CIPN.Western medicine focuses on alleviating numbness,pain,and other neurological reactions by addressing the local microenvironment.In contrast,Chinese medicine takes a holistic approach,emphasizing the nourishment of the whole body′s qi and blood to invigorate the tendons and meridians.Both Chinese medicine and western medicine have their own characteristics in terms of treatment theories and methods.

关 键 词：周围神经病变 化疗 化疗药物 中医 西医 研究进展 

分 类 号：R242[医药卫生—中医临床基础] R273[医药卫生—中医学]