补肾益经汤联合戊酸雌二醇治疗卵巢早衰闭经效果及对性激素和卵巢的影响  

Effect of Bushen Yijing decoction combined with estradiol valerate for treating patients with amenorrhea because of premature ovarian failure and its influence on sex hormone and ovarian volume the of the patients

作　　者：樊家乙 赵雅琳 王爱文 FAN Jiayi;ZHAO Yalin;WANG Aiwen(Hebei General Hospital for Retired Soldiers,Xingtai,Hebei Province,054000)

机构地区：[1]河北省退役军人总医院,邢台054000

出　　处：《中国计划生育学杂志》2024年第6期1275-1278,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨补肾益经汤联合戊酸雌二醇治疗卵巢早衰闭经效果及对性激素、卵巢的影响。方法:选择2021年1月-2023年1月本院接受治疗的85例卵巢早衰闭经患者,随机数表法分为中西药组(n=43)和对照组(n=42)。两组均给戊酸雌二醇治疗,中西药组联合补肾益经汤治疗。比较两组临床疗效、雌二醇(E_(2))、促卵泡生成素(FSH)、黄体生成素(LH)、子宫三径线之和、子宫内膜厚度、卵巢平均体积、中医症状积分及并发症。结果:治疗后,中西药组治疗总有效率(86.1%)高于对照组(66.7%),两组血清E_(2)均升高,FSH、LH水平均降低,且中西药组(93.25±7.56 pmol/L、14.13±3.04 U/L、11.24±2.31 U/L)变化幅度大于对照组(81.25±8.59 pmol/L、28.54±4.16 U/L、20.05±2.34 U/L),两组超声子宫三径线之和、子宫内膜厚度、卵巢平均体积均升高且中西药组(27.41±4.14 cm、8.69±0.99 mm、35.71±4.81 mm^(3))均高于对照组(23.52±4.08 cm、6.93±0.81 mm、33.10±4.40 mm^(3));两组阴道干涩、性欲下降、两胁胀痛及烦躁易怒评分均下降,且中西药组低于对照组(均P<0.05);治疗期间不良反应主要有轻度恶心、呕吐、乳房胀痛,两组总发生率无差异(9.3%、7.1%)(P>0.05)。结论:补肾益经汤联合戊酸雌二醇治疗卵巢早衰闭经临床效果提高,可更好改善患者性激素水平和卵巢功能。Objective:To explore the effect of Bushen Yijing decoction combined with estradiol valerate for treating patients with amenorrhea because of premature ovarian failure(POF),and to study its influence on the sex hormones level and ovary of the patients.Methods:85 patients with amenorrhea because of POF who treated in hospital were selected and were divided into experimental group(n=43)and control group(n=42)by random number table method from January 2021 to January 2023.The patients in the two groups were treated with estradiol valerate,and the patients in the experimental group were treated with Bushen Yijing decoction additionally.The clinical efficacy,the levels of estradiol(E_(2)),follicle-stimulating hormone(FSH)and luteinizing hormone(LH),the sum value of three diameters of uterus,the endometrial thickness,the average ovarian volume,the TCM symptom score and the rate of complications of the patients were compared between the two groups.Results:The total effective rate(86.1%)of the patients in the experimental group was significantly higher than that(66.7%)of the patients in the control group.The levels of serum E_(2) of the patients in the two groups had ircreased signifficantly and the levels of FSH and LH of the patients in the two groups had decreased significantly,and the changes of which(93.25±7.56 pmol/L,14.13±3.04U/L and 11.24±2.31 U/L)of the patients in the experimental group were significantly more than those(81.25±8.59pmol/L,28.54±4.16 U/L and 20.05±2.34 U/L)of the patients in the control group.The sum value of three uterine diameters,the endometrial thickness and the ovarian average volume of the patients in the two groups had increased significantly,and which(27.41±4.14 cm,8.69±0.99 mm and 35.71±4.81 mm^(3))of the patients in the experimental group were significantly higher than those(23.52±4.08 cm,6.93±0.81)mm and (33.10±4.40 mm^(3))of the patients in the control group.The scores of the vaginal dryness,the decreased sexual desire,the flank swelling pain and the irritability of the pat

关 键 词：卵巢早衰闭经 补肾益经汤 戊酸雌二醇 性激素 卵巢体积 疗效 

分 类 号：R711.75[医药卫生—妇产科学]