精蛋白人胰岛素注射液对GDM患者血糖及妊娠结局的影响  

rCfects of arginine human insulin injection for treating pregnant women with gestational diabetes mellitus on their blood glucose and pregnancy outcomes

作　　者：丁成红 邓晓媚 许凤琴 王艳枫 孔玲玲 DING Chenghong;DENG Xiaomei;XU Fengqin;WANG Yanfeng;KONG Lingling(Lujiang County People's Hospital Hefei,Anhui Province,231500;The First Affiliated Hospital of the University of Science and Technology of China(Anhui Provincial Hospital))

机构地区：[1]安徽省庐江县人民医院,231500 [2]中国科学技术大学附属第一医院,安徽省立医院

出　　处：《中国计划生育学杂志》2024年第6期1290-1294,共5页Chinese Journal of Family Planning

摘　　要：目的:探究门冬胰岛素联合精蛋白人胰岛素注射液治疗妊娠期糖尿病(GDM)对患者血红蛋白(HGB)、C反应蛋白(CRP)、C肽(CP)及血糖和安全性影响。方法:选取2020年12月-2023年12月本院治疗的GDM患者106例,双色球分组法分为常规组和观察组各53例。两组均给予门冬胰岛素降糖治疗,观察组给予精蛋白合成人胰岛素注射治疗,两组均治疗2个月。治疗前后分别检测空腹血糖(FBG)、糖化血红蛋白(HbA1c)和餐后2 h血糖(2hPG)水平,空腹胰岛素(FINS)水平并计算胰岛素抵抗指数(HOMA-IR),HGB、CP、CRP和白介素-6(IL-6)水平;收集两组不良妊娠结局。结果:治疗2个月后两组FBG、HbAlc、2hPG、HOMA-IR、HGB、CRP和IL-6均降低,且观察组(4.06±0.28 mmol/L、4.15%±0.26%、5.05±0.36 mmol/L、2.29±0.47、134.79±5.32 g/L、5.01±0.12 mg/L、6.33±0.70 ng/ml)均低于常规组(5.11±0.48 mmol/L、5.31%±0.56%、6.46±0.38mmol/L、2.52±0.56、138.12±9.95g/L、6.96±0.34mg/L、7.59±0.82ng/ml),两组FINS、CP均升高,且观察组(8.61±0.38 mU/L、1.90±0.26mg/L)高于常规组(7.89±0.31mU/L、1.67±0.22 mg/L),不良妊娠结局发生率观察组(11.3%)低于常规组(32.1%)(均P<0.05)。结论:门冬胰岛素联合应用精蛋白人胰岛注射液治疗GDM,可有效改善患者血糖水平,升高HGB和CP水平,降低炎症因子水平和不良妊娠结局,临床应用效果和安全性均较好。Objective:To investigate the effects of applying arginine human insulin injection for treating pregnant women with gestational diabetes mellitus(GDM)on their levels of hemoglobin(HGB),C-reactive protein(CRP),C-peptide(CP)and blood glucose,and their safety.Methods:106 pregnant women with GDM who were admitted to hospital were selected and were divided into control group and observation group(53 cases in each group)by the two-color grouping method from December 2020 to December 2023.The women in the two groups were given the treatment of insulin aspart for treating their GDM for 2 months,the women in the control group were given the treatment of menthol insulin additionally and the women in the observation group were given the treatment of arginin-synthesized human insulin injection additionally.The levels of fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c)and 2 h postprandial glucose(2h PG)and fasting insulin(FINS)of the women in the two groups before and after treat-ment were detected.The homeostasis model assessment of insulin resistance(HOMA-IR)value of the women in the two groups was calculated.The levels of the HGB,CP,CRP and interleukin-6(IL-6)of the women in the two groups were also detected.The adverse pregnancy outcomes of the women in the two groups were collected.Results:The lev-els of FBG,HbA1c,2hPG,HGB,CRP and IL-6,and the HOMA-IR value of the women in both groups after 2 months of treatment had decreased significantly,and which(4.06±0.28 mmol/L,4.15%±0.26%,5.05±0.36 mmol/L,134.79±5.32 g/L,5.01±0.12 mg/L,6.33±0.70 ng/ml and 2.29±0.47)of the women in the observation group were significantly lower than those(5.11±0.48 mmol/L,5.31%±0.56%,6.46±0.38mmol/L,138.12±9.95g/L,6.96±0.34mg/L,7.59±0.82ng/ml and 2.52±0.56)of the women in the control group.The levels of FINS and CP of the women in both groups had increased significantly,and which(8.61±0.38 mU/L and 1.90±0.26mg/L)of the women in the observation group were significantly higher than those(7.89±0.31mU/L and 1.67±0.22 mg/L)of th

关 键 词：妊娠期糖尿病 精蛋白人胰岛素注射液 门冬胰岛素 炎症因子 血红蛋白 血糖 安全性 

分 类 号：R714.256[医药卫生—妇产科学]