加味二仙汤联合来曲唑对PCOS患者促排卵及血清性激素水平的影响  

Impacts of Jiawei Erxian decoction combined with letrozole for ovulation induction of patients with polycystic ovary syndrome on their levels of serum anti Mullerian hormone and sex hormones

作　　者：李晓娟 罗喜 张伶俐[3] LI Xiaojuan;LUO Xi;ZHANG Lingli(Hunan University of Traditional Chinese Medicine,Changsha,Hunan Province,410200;Hunan Provincial Hospital of Traditional Chinese medicine Affiliated to Hunan University of Traditional Chinese Medicine;First affiliated Hospital of Hunan College of Traditional Chinese Medicine)

机构地区：[1]湖南中医药大学,长沙410200 [2]湖南中医药大学附属省直中医医院 [3]湖南中医药高等专科学校附属第一医院

出　　处：《中国计划生育学杂志》2024年第6期1379-1382,1388,共5页Chinese Journal of Family Planning

摘　　要：目的:探究加味二仙汤联合来曲唑治疗多囊卵巢综合征(PCOS)对患者促排卵及血清抗缪勒管激素(AMH)等性激素水平的影响。方法:选取本院2020年3月-2023年8月确诊的PCOS患者86例,随机数字表法分为西药组(n=43)和中西药组(n=43)。两组均服用来曲唑治疗,中西药组加服加味二仙汤治疗,统计两组治疗前后促排卵情况(成熟卵泡个数、宫颈粘液评分、排卵期子宫内膜厚度),性激素[雌激素(E_(2))、促卵泡激素(FSH)、睾酮(T)、黄体生成素(LH)]水平,AMH水平以及不良反应。结果:治疗后,中西药组成熟卵泡个数(5.3±0.6个)、宫颈粘液评分(11.9±1.4分)、排卵期子宫内膜厚度(9.2±1.1mm)、妊娠率(74.4%)均高于西药组(3.8±0.5个、9.2±1.1分、6.5±0.9mm、46.5%),两组血清E_(2)、T、LH、AMH水平均降低,FSH两组均升高,且中西药组变化幅度大于西药组(均P<0.05);两组不良反应发生率(16.3%、9.3%)无差异(P>0.05)。结论:加味二仙汤联合来曲唑治疗PCOS,可显著改善患者排卵情况及性激素水平,降低AMH水平,提高治疗妊娠率。Objective:To investigate the impacts of Jiawei Erxian decoction combined with letrozole for ovulation induction of patients with polycystic ovary syndrome(PCOS)on their levels of serum anti Mullerian hormone(AMH)and sex hormones.Methods:86 patients with PCOS diagnosed in hospital were selected and were randomly divided into two groups(43 cases in each group)by random number table method from March 2020 to August 2023.The patients in the control group were treated with letrozole for ovulation induction,while the patients in the study group were treated with Jiawei Erxian decoction combined with letrozole for ovulation induction.The ovulation induction status before and after treatment,such as the number of mature follicles,cervical mucus score and endometrial thickness during ovulation,the levels of sex hormones,such as estrogen(E_(2)),follicle stimulating hormone(FSH),testosterone(T)and luteinizing hormone(LH),the AMH level and the adverse reactions rate of the patients in the two groups were statistically analyzed.Results:The number of mature follicles(5.3±0.6 follicles),the cervical mucus score(11.9±1.4points),the endometrial thickness during ovulation(9.2±1.1 mm)and the pregnancy rate(74.4%)of the patients in the study group were significantly higher than those(3.8±0.5 follicles,9.2±1.1 points,6.5±0.9 mm and 46.5%)of the patients in the control group.The levels of the serum E_(2),T,LH and AMH of the patients in the two groups had decreased significantly and the FSH levels of the patients in the two groups had increased significantly,and the changes of which of the patients in the study group were significantly greater than those of the patients in the control group(all P<0.05).There was no difference in the incidence of the adverse reactions(16.3%vs.9.3%)of the patients between the two groups(P>0.05).Conclusion:Jiawei Erxian decoction combined with letrozole for treating the patients with PCOS can significantly improve their ovulation situation and sex hormones levels,decrease their AMH level and increas

关 键 词：多囊卵巢综合征 来曲唑 加味二仙汤 促排卵 抗缪勒管激素 性激素 妊娠率 

分 类 号：R711.75[医药卫生—妇产科学]