HDP孕妇血清GGT、LDH、UA水平与病情程度及不良妊娠结局关系  

Coreelation of the levels of gamma glutamyl transpeptidase,lactate dehydrogenase and uric acid of pregnant women with hypertension disorders of pregnancy and their disease severity and adverse pregnancy outcomes

作　　者：张青青 闻明[1] 陈琦 ZHANG Qingqing;WEN Ming;CHEN Qi(Wuhu First People's Hospital,Wuhu,Anhui Province,241000)

机构地区：[1]安徽省芜湖市第一人民医院,241000

出　　处：《中国计划生育学杂志》2024年第6期1397-1401,共5页Chinese Journal of Family Planning

摘　　要：目的:分析妊娠期高血压疾病(HDP)患者血清γ-谷氨酰转肽酶(GGT)和乳酸脱氢酶(LDH)、尿酸(UA)、水平及与病情程度和不良妊娠结局关系。方法:选择2022年7月-2023年7月本院收治的HDP患者64例,依据病情严重程度分为单纯组(单纯HDP)20例、轻度组(轻度子痫前期)23例、重度组(重度子痫前期)21例,妊娠结局正常38例、不良26例。同期产前检查健康孕妇118例纳入健康组。比较各组临床资料,血清GGT、LDH、UA水平,分析GGT、LDH、UA表达与HDP病情程度的相关性,比较分析HDP患者不同妊娠结局者GGT、LDH、UA水平及其对妊娠结局的影响。结果:健康组、单纯组、轻度组、重度组血清血压、GGT、LDH、UA水平依次增高,Spearman分析显示,HDP严重程度与患者血清GGT、LDH、UA水平呈正相关(均P<0.05)。HDP患者不良妊娠结局者血清GGT、LDH、UA水平均高于正常妊娠结局者(P<0.05);logistic回归分析,血清GGT、LDH、UA高表达是导致HDP患者不良妊娠结局的危险因素(均P<0.05)。结论:HDP患者血清GGT、LDH、UA水平与疾病严重程度呈正相关,其高水平表达是不良妊娠结局的独立危险因素,可为临床治疗HDP及预后评估提供参考。Objective:To investigate the coreelation of the levels of gamma glutamyl transpeptidase(GGT),lactate dehydrogenase(LDH)and uric acid(UA)of pregnant women with hypertension disorders of pregnancy(HDP)and their disease severity and pregnancy outcomes.Methods:72 pregnant women with HDP admitted to hospital were selected in study group from July 2022 to July 2023.These women were divided into group A(20 women with HDP only),group B(23 women with mild preeclampsia)and group C(21 women with severe preeclampsia).There were 38women with normal pregnancy outcomes in group D and 26 women with adverse pregnancy outcomes in group E.118healthy pregnant women who had been antenatal examination were selected in control group during the same period.The clinical data,the levels of GGT,LDH and UA of the women were compared among these groups.The correlation of the levels of GGT,LDH and UA of the women with HDP and their disease severity was analyzed.The influence of the levels of GGT,LDH and UA of the women with HDP on their pregnancy outcomes was also analyzed.Results:The blood pressure value,and the serum GGT,LDH and UA levels of the women in the control group,in group A,in group B,and in group C had increased gradually.Spearman analysis showed that the HDP severity of the women was positively correlated with their serum GGT,LDH,and UA levels(all P<0.05).The serum GGT,LDH and UA levels of the women in group E were significantly higher than those of the women in group D(P<0.05).Logistic regression analysis showed that the high expressions of the serum GGT,LDH,and UA of the women with HDP were the risk factors leading to the adverse pregnancy outcomes of the women(all P<0.05).Conclusion:The GGT,LDH and UA levels of the women with HDP are positively correlated with their severity of HDP,and the high level expressions of which are the risk factors of the adverse pregnancy outcomes of the women,so the GGT,LDH and UA levels of the women with HDP can provide the references for the clinical treatment and the prognosis evaluation of the

关 键 词：妊娠期高血压疾病 疾病程度 Γ-谷氨酰转肽酶 乳酸脱氢酶 尿酸 不良妊娠结局 相关性 

分 类 号：R714.246[医药卫生—妇产科学]