妊娠合并HBV感染者血清IP-10、QSOX1水平及与母婴不良结局关系  

Correlation between the levels of serum interferon gamma induced protein 10 and sulfhydryloxidase 1 of pregnant women with hepatitis B virus infection and the maternal and infant outcomes

作　　者：卓亚 朱斌[1] 吴虹杰[1] ZHUO Ya;ZHU Bin;WU Hongjie(First Affiliated Hospital of Xinxiang Medical College,Xinxiang,Henan Province,453100)

机构地区：[1]新乡医学院第一附属医院,453100

出　　处：《中国计划生育学杂志》2024年第6期1420-1423,1428,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨妊娠合并乙肝病毒(HBV)感染孕妇血清干扰素γ诱导蛋白-10(IP-10)、巯基氧化酶1(QSOX1)水平与母婴不良结局关系。方法:回顾性选择2021年3月-2023年3月本院治疗的妊娠合并HBV感染孕妇86例为感染组,产前检查正常孕妇76例为对照组,检测所有孕妇血清IP-10、QSOX1水平并记录母婴结局,进行组间比较。采用多因素logistic回归模型对妊娠合并HBV感染者母婴结局的影响因素进行分析,采用受试者工作特征(ROC)曲线分析血清IP-10、QSOX1对妊娠合并HBV感染者母婴结局评估价值。结果:感染组血清IP-10(68.52±10.46 pg/ml)、QSOX1(75.62±11.50 ng/ml)水平均高于对照组(30.22±6.66 pg/ml、45.25±7.62 ng/ml),不良母婴结局发生率(50.0%)高于对照组(17.1%)(均P<0.05)。多因素logistic逐步回归分析显示,血清IP-10(OR=1.740,95%CI 1.403~2.159)、QSOX1(OR=4.225,95%CI 2.050~8.708)均为影响妊娠合并HBV感染者不良母婴结局的因素(P<0.05)。ROC曲线分析显示,血清IP-10、QSOX1评估妊娠合并HBV感染者不良母婴结局的曲线下面积(AUC)为0.854、0.867,二者联合评估效能提高(AUC=0.925)。结论:妊娠合并HBV感染者血清IP-10、QSOX1水平均升高,且二者水平变化均是影响孕妇不良母婴结局因素,且可作为评估不良母婴结局指标。Objective:To explore the correlation between the levels of serum interferon gamma induced protein 10(IP10)and sulfhydryloxidase 1(QSOX1)of pregnant women with hepatitis B virus(HBV)infection and the maternal and infant outcomes.Methods:86 pregnant women with HBV infection treated from March 2021 to March 2023 were selected in the study group retrospectively,and 76 normal pregnant women during the same period were selected in the control group.The levels of serum IP10 and QSOX1 detected and the maternal and infant outcomes of the women were recorded and were compared between the two groups.The influencing factors of the maternal and infant outcomes of the pregnant women with HBV infection were explored by multivariate logistic regression model.Receiver operator characteristic(ROC)curve was used to evaluate the diagnostic value of the serum IP10 and QSOX1 levels of the women for their maternal and infant outcomes.Results:The levels of serum IP 10(68.52±10.46 pg/ml)and QSOX1(75.62±11.50 ng/ml)of the women in the study group were significantly higher than those(30.22±6.66 pg/ml and45.25±7.62 ng/ml)of the women in the control group.The incidence of the adverse maternal and infant outcomes(50.0%)of the women in the study group was significantly higher than that(17.1%)of the women in the control group(all P<0.05).Multiple factors logistic stepwise regression analysis showed that the serum IP10 level(OR=1.740,95%CI 1.403-2.159),the serum QSOX1 level(OR=4.225,95%CI 2.050-8.708)of the women with HBV infection were the main factors affecting their adverse maternal and infant outcomes(P<0.05).ROC curve analysis showed that the area under curve(AUC)of the serum IP10 level,the QSOX1 level,or the combined levels of the IP10and QSOX1 of the women with HBV infected for evaluating their adverse outcomes of pregnancy were 0.854,0.867 or0.925,respectively.Conclusion:The levels of serum IP10 and QSOX1 of the pregnant women with HBV infection increase and the changes of the levels of serum IP10 and QSOX1 were the adverse influence

关 键 词：妊娠合并乙肝病毒感染 干扰素γ诱导蛋白-10 巯基氧化酶1 母婴不良结局 影响因素 评估价值 

分 类 号：R714.251[医药卫生—妇产科学]