中药防治化疗所致恶心呕吐的网络药理学研究  

Network Pharmacological Study on Traditional Chinese Medicine in the Prevention and Treatment of Chemotherapy-induced Nausea and Vomiting

作　　者：张舟妙 江滔[2] 李苗霞[1] ZHANG Zhoumiao;JIANG Tao;LI Miaoxia(Pharmacy Department,Xiangdong Hospital Affiliated to Hunan Normal University,Hunan Province,Zhuzhou 412200,China;Oncology Department,Xiangdong Hospital Affiliated to Hunan Normal University,Hunan Province,Zhuzhou 412200,China)

机构地区：[1]湖南师范大学附属湘东医院药剂科,湖南株洲412200 [2]湖南师范大学附属湘东医院肿瘤科,湖南株洲412200

出　　处：《中国中医药现代远程教育》2024年第15期91-94,共4页Chinese Medicine Modern Distance Education of China

基　　金：湖南省教育厅科学研究项目【No.20C1178】。

摘　　要：目的分析中药防治化疗所致恶心呕吐(CINV)的处方规律,探索其作用靶点及相关信号通路,揭示可能的作用机制。方法收集中药防治CINV的方剂,应用中医传承辅助平台V 2.5分析组方规律,筛选核心药物;应用中医药整合药理学研究平台(TCMIP)v 2.0探索核心药物防治CINV的作用靶点和信号通路。结果收集、处理后,得到方剂119首,生姜出现的频次最高(49次),其次是半夏(39次)、人参(39次);得到6891个靶点基因,富集到157条信号通路。结论大半夏汤为中药防治CINV的核心方剂,其作用机制与抑制炎症反应相关,可能通过调控肿瘤坏死因子(TNF)信号通路、高级糖基化终末产物-受体(AGE-RAGE)信号通路实现。Objective To analyze the prescription rules of traditional Chinese medicine(TCM)in the prevention and treatment of chemotherapy-induced nausea and vomiting(CINV),to explore its action targets and related signal pathways,so as to reveal its possible mechanism of action.Methods The prescriptions of TCM in treatment of CINV were collected from the Internet.TCM inheritance platform system v2.5 software were used to analyze the prescription rules and screen the core herbs.TCMIP v2.0 were used to investigate the targets and signal pathways of core herbs.Results Among the 119 prescriptions of TCM in the treatment of CINV,ginger was at highest frequency(49 times),followed by pinellia ternate(39 times)and ginseng(39 times).6891 related targets and 157 related pathways were collected.Conclusion Based on network pharmacology,it was proposed that the mechanism of TCM in treating CINV is to inhibit inflammatory reaction,which may be achieved by regulating TNF signal pathway and AGE-RAGE signal pathway.

关 键 词：化疗所致恶心呕吐 网络药理学 中药 

分 类 号：R28[医药卫生—中药学]