二陈汤加减联合多烯磷脂酰胆碱胶囊治疗代谢相关脂肪性肝病临床观察  

Clinical efficacy of Erchen Decoction combined with polyene phosphatidylcholine capsules on metabolic-associated fatty liver disease

作　　者：孙天琪 卢秉久[2] 郑佳连[2] SUN Tianqi;LU Bingjiu;ZHENG Jialian(2021 graduate student,Liaoning University of Traditional Chinese Medicine,Shenyang,Liaoning 110847;Department of Hepatology,Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang,Liaoning 110032)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属医院肝病科,辽宁沈阳110032

出　　处：《河北中医》2024年第6期936-940,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：辽宁省教育厅2019年度科学研究经费项目(编号:L201903)。

摘　　要：目的观察二陈汤加减联合多烯磷脂酰胆碱胶囊治疗代谢相关脂肪性肝病(MAFLD)的临床疗效。方法将196例MAFLD患者按照随机数字表法分为2组,均对患者饮食方式、生活方式等进行常规指导,治疗组98例予二陈汤加减联合多烯磷脂酰胆碱胶囊治疗,对照组98例予多烯磷脂酰胆碱胶囊治疗,2组均治疗12周。比较2组疗效;比较2组治疗前后体质量指数(BMI)、腰围、肝功能指标、血脂指标、B超评分、症状评分变化。结果治疗组总有效率90.82%(89/98),对照组总有效率76.53%(75/98),治疗组疗效优于对照组(P<0.05)。治疗组治疗第4、8、12周BMI均较本组治疗前降低(P<0.05),治疗组治疗第8、12周BMI均较本组治疗第4周降低(P<0.05)。对照组治疗前及治疗第4、8、12周BMI比较差异均无统计学意义(P>0.05)。治疗组治疗第4、8、12周BMI改善均优于对照组(P<0.05)。2组治疗后腰围均较本组治疗前降低(P<0.05)。2组治疗第4、8、12周ALT、AST、γ-GT水平均较本组治疗前降低(P<0.05);治疗组治疗第4、8、12周ALT水平均低于对照组治疗同期(P<0.05);治疗组治疗第8、12周AST水平均低于对照组治疗同期(P<0.05)。2组治疗第4、8、12周TC、TG水平均较本组治疗前降低(P<0.05),治疗第4、8、12周HDL-C水平均较本组治疗前升高(P<0.05);治疗组治疗第4、8、12周TC、TG水平均低于对照组治疗同期(P<0.05),治疗第8、12周HDL-C水平均高于对照组治疗同期(P<0.05)。2组治疗后B超评分均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。2组治疗后各项症状评分均较本组治疗前降低(P<0.05),且治疗组降低更明显(P<0.05)。结论二陈汤加减联合多烯磷脂酰胆碱胶囊治疗MAFLD,能降低BMI,缩小腰围,改善患者肝功能、血脂水平,改善B超评分和症状。Objective To observe the clinical efficacy of Erchen Decoction combined with polyene phosphatidylcholine capsules on metabolic-associated fatty liver disease(MAFLD).Methods A total of 196 patients with MAFLD were divided into control group(n=98)and treatment group(n=98)according to a random number table.All patients were given routine guidance on diet and lifestylem,patients in the treatment group additonally received modified Erchen Decoction puls polyene phosphatidylcholine capsules.But those in the control group received the later only.A 12-week treatmeat was performed.The curative effects of the two groups were compared.The changes in body mass index(BMI)and waist circumference(WC),indexes of liver function and blood lipid,scores of B-ultrasound examination and traditional Chinese medicine(TCM)symptom before and after treatment were included as comparators between the two groups.Results The total effective rate in the treatment group was significantly higher than that of the control group(90.81%[89/98]vs 76.53%[75/98],P<0.05).The levels of BMI in the treatment group at weeks 4,8 and 12 were significantly lower than those before treatment(P<0.05).The levels of BMI of the treatment group at weeks 8 and 12 were significantly lower than those at week 4(P<0.05).There was no significant difference in BMI level in the control group before and after treatment(P>0.05).The improvement of BMI in the treatment group was significantly better than that of the control group(P<0.05).The levels of WC in the two groups after treatment were significantly lower than those before treatment(P<0.05).The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),gamma-glutamyltransferase(γ-GT)in the two groups at weeks 4,8 and 12 were significantly lower than those before treatment(P<0.05).The levels of ALT at weeks 4,8 and 12 in the treatment group were significantly lower than those of the control group(P<0.05).The levels of AST at weeks 8 and 12 in the treatment group were significantly lower than those of the contr

关 键 词：肝疾病 非酒精性 中西医结合疗法 

分 类 号：R349.1[医药卫生—基础医学]