盆腔器官脱垂患者阴道前壁神经分布与脱垂程度的关系  

Relationship between anterior vaginal wall nerve distribution and prolapse degree in patients with pelvic organ prolapse

作　　者：杨文娟 林益琴 孙先军 YANG Wenjuan;LIN Yiqin;SUN Xianjun(Department of Gynecology,Jiaxing Maternity and Child Health Care Hospital,Jiaxing 314001,CHINA)

机构地区：[1]嘉兴市妇幼保健院妇科,浙江314001

出　　处：《江苏医药》2024年第5期465-467,I0003,共4页Jiangsu Medical Journal

基　　金：嘉兴市科技计划项目(2021AD30030)。

摘　　要：目的分析盆腔器官脱垂(POP)患者阴道前壁神经分布与脱垂程度的关系。方法采用免疫组化染色法检测行手术治疗的138例POP患者阴道前壁黏膜组织中蛋白基因产物9.5(PGP9.5)表达,并根据PGP9.5表达分为弱阳性(A组,25例)、阳性(B组,77例)和强阳性(C组,36例)三组。比较三组POP相关指标和脱垂程度。结果POP患者阴道前壁黏膜上皮下层及固有层均可见PGP9.5阳性表达。三组POP相关指标比较均无统计学差异(P>0.05)。A组和B组Ba点和C点数值均大于C组(P<0.05或P<0.01)。结论POP患者阴道前壁神经分布与脱垂程度相关。阴道前壁神经分布密集的POP患者的脱垂程度相对较轻。Objective To analyze the relationship between anterior vaginal wall nerve distribution and prolapse degree in the patients with pelvic organ prolapse(POP).MethodsImmunohistochemical staining was used to detect the expression of protein gene product 9.5(PGP9.5)in the mucosal tissues of anterior vaginal wall in 138 patients with POP underwent surgical treatment.According to PGP9.5 expression,25 cases were weakly positive(group A),77 cases were positive(group B)and 36 cases were strongly positive(group C).The POP-related indexes and prolapse degree of the three groups were compared.Results The positive expression of PGP9.5 was found in the subepithelial mucosa and lamina propria of anterior vaginal wall in POP patients.There were no significant differences in the POP-related indexes among the three groups(P>0.05).The values of Ba and C points in groups of A and B were greater than those in group C(P<0.05 or P<0.01).Conclusion Anterior vaginal wall nerve distribution in POP patients is correlated with the prolapse degree.The milder prolapse degree was found in the POP patients with dense anterior vaginal wall nerve distribution.

关 键 词：盆腔器官脱垂 蛋白基因产物9.5 神经分布 

分 类 号：R713[医药卫生—妇产科学]