基于成分配伍的中药复方研究策略  

Chinese medicine formula research strategy based on compound compatibility

作　　者：张宏 李奇璋 刘爱芬[2] 曾克武[3] 丁显廷 王博谦 史建伍 王成牛[2] 辛海量 张磊 ZHANG Hong;LI QiZhang;LIU AiFen;ZENG KeWu;DING XianTing;WANG BoQian;SHI Jian Wu;WANG ChengNiu;XIN HaiLiang;ZHANG Lei(Innovative Drug Research Center,College of Life Sciences,Huaibei Normal University,Huaibei 235000,China;Medical School of Nantong University,Nantong 226001,China;State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China;State Key Laboratory of Oncogenes and Related Genes,Institute for Personalized Medicine,School of Biomedical Engineering,Shanghai Jiao Tong University,Shanghai 200030,China;School of Pharmacy,Naval Medical University,Shanghai 200433,China)

机构地区：[1]淮北师范大学生命科学学院创新药物研究中心,淮北235000 [2]南通大学医学院,南通226001 [3]北京大学药学院,天然药物及仿生药物全国重点实验室,北京100191 [4]上海交通大学生物医学工程学院,个性化医学研究院,癌基因及相关基因国家重点实验室,上海200030 [5]海军军医大学药学院,上海200433

出　　处：《中国科学：生命科学》2024年第5期911-924,共14页Scientia Sinica(Vitae)

基　　金：国家自然科学基金(批准号:82174023,82225047)资助。

摘　　要：传统中药复方的功效已被长期临床实践所证实,但由于包含复杂的化学成分,其安全性、有效性和质量稳定性难以控制.组分中药尽管促进了中医药的发展,但仍然难以明确作用靶点及分子机制,无法清楚阐释方剂配伍理论的科学内涵.本文提出基于有效成分配伍的中药复方(成分中药)研究策略,涉及的关键技术主要包括:(ⅰ)入血/组织化学成分分析;(ⅱ)三维筛选模型构建;(ⅲ)作用靶点研究;(ⅳ)数据整合分析.成分中药既具有传统方剂协同增效减毒的优势,体现了配伍特色,同时又具有现代药物成分清楚的特点,能借助多学科技术明确各成分作用靶点及协同分子机制,从而可清楚阐释方剂配伍理论的科学内涵,是今后中药复方研究的必然发展趋势.该研究策略的提出对从方法学角度解决中医药原创理论的现代科学内涵阐述等重大前沿科学问题具有示范意义.The efficacy of traditional Chinese medicine formulas has been validated during its long-term clinical practice.However,controlling their safety,effectiveness,and quality stability is difficult owing to their complex chemical composition.Although studies on component-based Chinese medicines have promoted the development of traditional Chinese medicine,further elucidating their targets and molecular mechanisms of action is still difficult,and the scientific connotation of the formula compatibility theory remains unclear.Thus,we propose a research strategy for Chinese medicine formulas based on active compound compatibility,i.e.,compound-based Chinese medicine formula(CCMF).The key technology challenges include the following:(i)analysis of chemical composition absorbed into the blood or tissues,(ii)construction of a three-dimensional screening model,(i)research on functional targets,and(iv)data integration and analysis.CCMF possesses not only advantages such as synergistic effects and toxicity reduction for traditional prescriptions with compatibility features but also a clear composition similar to modern medicines.Furthermore,the scientific connotation of the formula compatibility theory can be clearly elucidated using multidisciplinary technology to verify targets and synergistic molecular mechanisms of CCMF.This is an inevitable direction of the development of research on traditional Chinese medicine prescriptions in the future.The research strategy proposed in this study can help address major research challenges,such as the scientific interpretation of the original theories of traditional Chinese medicine from a methodological perspective.

关 键 词：复方 成分 配伍 策略 科学内涵 

分 类 号：R289.1[医药卫生—方剂学]