24690例不寐病患者临床症状表现特征分布的多中心横断面研究  

Multi-center cross-sectional study on the distribution of clinical symptoms in 24 690 patients with insomnia

作　　者：陈旭 张星平 侯文[3] 范天祥 王尧 魏小东 胡龙涛 王凯[8] 宋磊[9] 和玉松 CHEN Xu;ZHANG Xingping;HOU Wen;FAN Tianxiang;WANG Yao;WEI Xiaodong;HU Longtao;WANG Kai;SONG Lei;HE Yusong(The Fourth Clinical Medical School of Xinjiang Medical University,Urumqi 830054,China;The Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University,Urumqi 830099,China;The Affiliated Hospital of Shanxi University of Chinese Medicine,Xianyang 712000,China;Sichuan Provincial People's Hospital,Chengdu 610072,China;The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China;The People's Hospital of Changji Hui Autonomous Prefecture,Changji 831199,China;The Second Affiliated Hospital of Shaanxi University of Chinese Medicine,Xi'an 712046,China;Ankang Hospital of Guangzhou University of Chinese Medicine,Ankang 725000,China;Xinjiang Mental Health Center,Urumqi 830002,China;People's Hospital of Tongchuan District in Dazhou City,Dazhou 635099,China)

机构地区：[1]新疆医科大学第四临床医学院,乌鲁木齐830054 [2]新疆医科大学附属中医医院,乌鲁木齐830099 [3]陕西中医药大学附属医院,咸阳712000 [4]四川省人民医院,成都610072 [5]新疆医科大学第一附属医院,乌鲁木齐830054 [6]新疆昌吉州人民医院,新疆昌吉831199 [7]陕西中医药大学第二附属医院,西安712046 [8]广州中医药大学附属安康医院,陕西安康725000 [9]新疆精神卫生中心,乌鲁木齐830002 [10]达州市通川区人民医院,四川达州635099

出　　处：《中华中医药杂志》2024年第5期2377-2381,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.82160873,No.81960837,No.81560762,No.81260526);全国名老中医药专家传承工作室(No.国中医药人教函[2022]75号);新疆“十四五”中医学重点学科(No.新教函[2022]112号);新疆维吾尔自治区自然科学基金重点项目(No.2022D01D48);新疆医科大学研究生创新项目(No.CXCY2023006)。

摘　　要：目的:通过多中心横断面研究,了解不寐病患者直接症状表现特征分布。方法:采用多中心横断面研究,选取2018年1月至2023年9月9个临床研究分中心符合纳入标准的不寐病患者病例资料中患者的一般资料(性别、年龄、职业、婚姻、学历)及不寐主要直接症状与次要直接症状,观察各临床研究分中心病例纳入情况、不同年龄段不寐患者主要直接症状表现特征分布情况、不寐主要直接症状表现特征与次要直接症状表现特征间联系的频数分布,并比较不同主要直接症状表现特征不寐患者一般资料。结果:不寐病直接症状分别为入寐维艰类、夜寐梦多类、思虑纷纭类、轻浅易寤类、夜寐早寤类5类或以上5类的不同排列组合;不寐病直接症状呈现单一类型者约占37.92%(9 363/24 690),复合症状类型者约占62.08%(15 327/24 690);不同主症间不寐病患者在性别分布、平均年龄、职业性质、婚姻及学历状况方面差异有统计学意义(P<0.05);不寐病男、女患者比例为1∶1.52;41岁及以上人群是不寐患者的主体,占比79.51%(19 632/24 690);5类不同主症中,思虑纷纭类患者平均年龄偏小,夜寐早寤类偏大;不寐病主要直接症状由多至少依次为入寐维艰类、夜寐梦多类、轻浅易寤类、夜寐早寤类、思虑纷纭类。结论:不寐病患者直接症状可分为入寐维艰类、夜寐梦多类、思虑纷纭类、轻浅易寤类、夜寐早寤类5种类型,多数患者表现为以上5类的不同排列组合。Objective: To understand the distribution and clinical significance of the direct symptoms of insomnia patients through multi-center cross-sectional research. Methods: A multi-center cross-sectional study was used to collect the general data(gender, age, occupation, marriage, education) and main and secondary direct symptoms of insomnia patients from 9 clinical research subcenters meeting the inclusion criteria from January 2018 to September 2023. The inclusion of cases in each clinical research center, the distribution of main direct symptom characteristics in patients with insomnia in different age groups,and the frequency distribution of the connection between main direct symptom characteristics and secondary direct symptom characteristics of insomnia were observed, and the general data of patients with insomnia with different main direct symptom characteristics were compared. Results: The direct symptoms of insomnia were divided into five categories: Difficulty falling asleep, frequent dreams, mental confusion, easy wake-up and early wake-up, and there was no combination of other symptoms except for the above five categories. About 37.92%(9 363/24 690) of insomnia patients had single type symptoms while about 62.08%(15 327/24 690) had combined symptoms. There were differences in gender distribution, average age, professional nature,marital status and educational level among different types of insomnia patients(P<0.05). The ratio of male to female insomnia patients was 1:1.52. Patients aged over 41 years old accounted for 79.51%(19 632/24 690) of all insomnia patients. Among the five types of symptoms, patients with mental confusion had a younger average age while those with early wake-up had a older one. The main direct symptoms of insomnia in order from most common to least common are: difficulty falling asleep, easy wakeup, frequent dreams, early wake-up and mental confusion. Conclusion: The direct symptoms of insomnia can be divided into five types: difficulty falling asleep, frequent dreams, mental confus

关 键 词：不寐 直接症状 症状特征 不寐五神分型 失眠 多中心横断面研究 

分 类 号：R256.23[医药卫生—中医内科学]