基于fNIRS技术的不同针刺补泻手法中枢响应特征研究  

Research on central responses to different acupuncture manipulations with reinforcing-reducing based on f NIRS

作　　者：曹静雅 瞿玉竹 陈丽[5] 刘天宇 郭静[1,2,3] 龚玉来[7] 田子雷 熊静 林贞仿 杨馨 尹涛 曾芳 CAO Jingya;QU Yuzhu;CHEN Li;LIU Tianyu;GUO Jing;GONG Yulai;TIAN Zilei;XIONG Jing;LIN Zhenfang;YANG Xin;YIN Tao;ZENG Fang(Acupuncture and Tuina School,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Key Laboratory of Acupuncture for Senile Disease(Chengdu University of Traditional Chinese Medicine),Ministry of Education,Chengdu 611137,China;Acupuncture and Brain Science Research Center,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Post-Doctoral Scientific Research Workstation of Affiliated Sport Hospital,Chengdu Sport University,Chengdu 610041,China;Shanghai Fourth People's Hospital Affiliated to Tongji University,Shanghai 200000,China;Sport and Healthy School,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Sichuan Provincial Rehabilitation Hospital,Chengdu 611135,China;Rehabilitation Medicine Center,West China Hospital,Sichuan University,Chengdu 611135,China;Health and Rehabilitation School,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)

机构地区：[1]成都中医药大学针灸推拿学院,成都611137 [2]针灸防治老年疾病教育部重点实验室,成都611137 [3]成都中医药大学针灸脑科学研究中心,成都611137 [4]成都体育学院附属体育医院博士后工作站,成都610041 [5]同济大学附属上海市第四人民医院,上海200000 [6]成都中医药大学体育学院,成都611137 [7]四川省八一康复中心,成都611135 [8]四川大学华西医院康复医学中心,成都611135 [9]成都中医药大学养生康复学院,成都611137

出　　处：《中华中医药杂志》2024年第5期2417-2422,共6页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金杰出青年科学基金项目(No.82225050);国家自然科学基金青年科学基金项目(No.82205285);青年岐黄学者基金,四川省自然科学基金项目(No.2023NSFSC1818)。

摘　　要：目的:采用功能近红外光谱成像技术(fNIRS)对比平补平泻法、提插补法、提插泻法3种不同针刺补泻手法中枢应答模式的异同。方法:35名健康受试者按照随机顺序分别接受3种针刺手法并同时进行fNIRS扫描。采用基于一般线性模型的激活分析方法与基于种子点的功能连接分析方法探讨3种针刺手法的中枢响应特征。结果:3种针刺手法均可显著引起大脑皮层的功能活动变化,并显著增强脑区间功能连接(PFDR<0.05)。双侧背外侧前额叶皮层(DLPFC)及左侧初级躯体感觉皮层(S1)是不同针刺手法激活模式差异的脑区(PFDR<0.05)。结论:双侧DLPFC及左侧额顶网络(FPN)是不同针刺补泻手法共同作用的脑区。双侧DLPFC及左侧S1可能是不同针刺补泻手法作用差异的潜在靶点脑区。Objective:To investigate the central-response modes during the even reinforcing-reducing manipulation with lifting-thrusting(ERR),the lifting-thrusting reinforcing manipulation(LTRei),and the lifting-thrusting reducing manipulation(LTRed)by functional near-infrared spectroscopy(fNIRS).Methods:A total of 35 healthy male participants were included in this random crossover-design study.fNIRS data were recorded during the LTRei,LTRed,and ERR.The cortical activation analysis based on general linear model based(GLM)and the functional connectivity(FC)based on regions of interest(ROIs)analysis were combined to be conducted.Results:Three acupuncture manipulations all induced significantly cortical hemodynamic responses and increased functional connectivity between brain regions(PFDR<0.05).Different cortical hemodynamic responses were elicited by three acupuncture manipulations in bilateral dorsolateral prefrontal cortex(DLPFC)and left primary sensory cortex(S1)(PFDR<0.05).Conclusion:Bilateral DLPFC and left frontoparietal network are common brains in response to different acupuncture manipulations.Bilateral DLPFC and left S1 might be the potential brain regions that for different effects of different acupuncture with reinforcing-reducing manipulations.

关 键 词：针刺补泻手法 功能近红外光谱成像技术 中枢响应 大脑皮层激活 功能连接 

分 类 号：R246[医药卫生—针灸推拿学]