人类白细胞抗原G与COVID-19研究进展  

Progress in human leukocyte antigen G in the progression of COVID-19

作　　者：林爱芬 颜卫华 Lin Aifen;Yan Weihua(Biological Resource Center,Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou 317000,China;Medical Research Center,Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou 317000,China)

机构地区：[1]温州医科大学附属台州医院生物资源中心,台州317000 [2]温州医科大学附属台州医院中心实验室,台州317000

出　　处：《中华微生物学和免疫学杂志》2024年第5期441-446,共6页Chinese Journal of Microbiology and Immunology

基　　金：浙江省科技计划(2020R52060)。

摘　　要：宿主抗病毒免疫应答对于入侵病毒清除和疾病控制至关重要。COVID-19患者常见免疫细胞数量显著减少和功能耗竭,与疾病严重程度和不良预后密切相关。人类白细胞抗原G(human leucocyte antigen G,HLA-G)是一种重要的免疫检查点分子,能特异性结合免疫细胞表达的多种免疫抑制性受体,系统性抑制机体免疫应答。近来研究显示,HLA-G基因多态性及其分子表达对SARS-CoV-2易感性及COVID-19疾病进展具有重要意义。本文就HLA-G基因及分子特点、HLA-G/受体信号转导与免疫功能调节、HLA-G与COVID-19疾病进展等方面进行综述。Host immune response to viruses is critical for virus clearance and disease control.Dramatically decreased numbers and exhaustion of immune cells are common in COVID-19 patients,which is found to be closely related to the severity of the disease and poor prognosis.Human leukocyte antigen G(HLA-G)is an important immune checkpoint that can specifically bind to various immunosuppressive receptors expressed by immune cells,and systematically suppress the host immune response.Recent studies have shown that HLA-G gene polymorphism and its expression are of great significance for susceptibility to SARS-CoV-2 and the progression of COVID-19.In this review,the genetic and molecular characteristics of HLA-G,HLA-G/receptor signaling and immune function regulation,and its clinical significance in COVID-19 progression are summarized.

关 键 词：人类白细胞抗原G SARS-CoV-2 COVID-19 免疫应答 易感性 

分 类 号：R392[医药卫生—免疫学]