Ancylostoma ceylanicum and other zoonotic canine hookworms:neglected public and animal health risks in the Asia-Pacific region  

作　　者：Jan Clyden B.Tenorio lan Kim B.Tabios Tawin Inpankaew Adrian P.Ybanez Saruda Tiwananthagorn Sirikachorn Tangkawattana Sutas Suttiprapa 

机构地区：[1]Tropical Medicine Graduate Program,Faculty of Medicine,Khon Kaen University,Khon Kaen 40002,Thailand [2]Department of Tropical Medicine,Faculty of Medicine,Khon Kaen University,Khon Kaen 40002,Thailand [3]WHO Collaborating Center for Research and Control of Opisthorchiasis(Southeast Asian Liver Fluke Disease),Tropical Disease Research Center,Khon Kaen University,Khon Kaen 40002,Thailand [4]Department of Veterinary Paraclinical Sciences,College of Veterinary Medicine,University of Southern Mindanao,Kabacan,9407 Cotabato,Philippines [5]Institute of Biology,College of Science,University of the Philippines Diliman,Manila 1101,Philippines [6]Department of Parasitology,Faculty of Veterinary Medicine,Kasetsart University,Bangkok 10900,Thailand [7]College of Veterinary Medicine at Barili Campus and Center for Vector-Borne and Protozoan Diseases at Main Campus,Cebu Technological University,Cebu City 6000,Philippines [8]Department of Veterinary Biosciences and Public Health,Faculty of Veterinary Medicine,Chiang Mai University,Chiang Mai 50100,Thailand [9]Research Center for Veterinary Biosciences and Veterinary Public Health,Chiang Mai University,Chiang Mai 50100,Thailand [10]Faculty of Veterinary Medicine,Khon Kaen University.Khon Kaen 40002,Thailand

出　　处：《Animal Diseases》2024年第1期59-74,共16页动物疾病（英文）

摘　　要：Zoonotic hookworm infections remain a significant public health problem,causing nearly 500 milion cases globally and approximately four million disability-adjusted life years lost annually.More than one-fth of these cases are attrib-uted to Ancylostoma ceylanicum,an emerging zoonotic health issue in the Asia-Pacific region.This review presents key research gaps regarding the epidemiology,diagnosis,control,prevention and elimination of A.ceylanicum and other canine zoonotic hookworms as neglected health threats.A.ceylanicum is the second most prevalent human hook-worm in the region;it is the most common hookworm among dogs and cats-reservoirs of zoonotic infections.Previous population genetic and phylogenetic analyses revealed that A.ceylanicum has three possible transmis-sion dynamics:zoonotic,animal-only,and human-only pathways.The actual burden of zoonotic ancylostomiasis in most endemic countries remains unknown due to the use of parasitological techniques(e.g.,Kato-Katz thick smear and floatation techniques)that have reduced diagnostic performance and do not allow accurate species identifica-tion in helminth surveys.The emergence of benzimidazole resistance in soil-transmitted helminths(STHs),includ-ing hookworms,is a concern due to the protracted implementation of mass drug administration(MDA).Resistance is conferred by single nucleotide polymorphisms(SNPs)that occur in theβ-tubulin isotype 1 gene.These mutations have been reported in drug-resistant A.caninum but have not been found in A.ceylanicum in the field.A.ceylanicum remains understudied in the Asia-Pacific region.The zoonotic nature of the parasite warrants investigation of its occur-rence in human and animal reservoir hosts to understand the dynamics of zoonotic transmission in different endemic foci.The detection of benzimidazole resistance-associated SNPs in zoonotic hookworms from Asia-Pacific countries has yet to be thoroughly explored.Considering the high level of hookworm endemicity in the region,the circulation of resistant isolates between

关 键 词：Soil-transmitted helminths Neglected tropical diseases Mass drug administration DEWORMING Veterinary public health 

分 类 号：R535[医药卫生—内科学]