DLX3(Q178R)mutation delays osteogenic differentiation via H19/miR-29c-3p/KDM5B axis in TDO-iPSCs-derived MSCs  

作　　者：Liying Dong Na Zhao Dongmei Wang Meng Wang Yixin Zhang Liangjie Sun Chong Ding Yixiang Wang Zeyun Ma 

机构地区：[1]Central Laboratory,Peking University School and Hospital of Stomatology,Beijing 100081,China [2]Department of Oral and Maxillofacial Surgery,Peking University School and Hospital of Stomatology,Beijing 100081,China [3]National Engineering Laboratory for Digital and Material Technology of Stomatology,Peking University School and Hospital of Stomatology,Beijing 100081,China [4]Beijing Key Laboratory of Digital Stomatology,Peking University School and Hospital of Stomatology,Beijing 100081,China [5]The Second Clinical Division,Peking University School and Hospital of Stomatology,Beijing 100081,China [6]Department of VIP Service,Peking University School and Hospital of Stomatology,Beijing 100081,China [7]Department of Restorative Dentistry and Biomaterials Sciences,Harvard School of Dental Medicine,Boston,MA 02115,USA [8]Department of Prosthodontics,Fudan University,Shanghai 200001,China [9]Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases,Shanghai Stomatological Hospital,Fudan University,Shanghai 200001,China

出　　处：《Genes & Diseases》2024年第4期49-52,共4页基因与疾病（英文）

基　　金：supported by the National Nature Science Foundation of China(No.81970920,81900983);the Natural Science Foundation of Beijing Municipality,China(No.7232218);the Shanghai Science and Technology Committee Youth Sailing Program(China)(No.19YF1442500).

摘　　要：Tricho-dento-osseous(TDO)syndrome is a rare autosomal dominant disease resulting from distal-less homeobox 3(DLX3)mutation.1,2 Accumulative bone density in alveolar bone is a clinically favorable phenotype for TDO patients.However,the limited number of bone marrow mesenchymal stem cells(BMSCs)in TDO patients restricts their application.

关 键 词：patients clinically ALVEOLAR 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]