Single-cell transcriptomics systematically discloses the immune-inflammatory responses of peripheral blood mononuclear cells for diabetic nephropathy  

作　　者：Jiangpeng wu Nan Hu Baochun Guo Hualin Ma Lulin Xie Yisha Huang Siyu Xia Yuke Jiang Zhije Li Jigang Wang Xinzhou Zhang Zhen Liang 

机构地区：[1]Department of Nephrology,Shenzhen Key Laboratory of Kidney Diseases,and Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital(The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,Guangdong 518020,China [2]Department of Geriatrics,and Shenzhen Clinical Research Centre for Geriatrics,Shenzhen People's Hospital(The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,Guangdong 518020,China [3]State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Artemisinin Research Center,and Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China

出　　处：《Genes & Diseases》2024年第4期82-85,共4页基因与疾病（英文）

基　　金：supported by the Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties(China)(No.SZGSP001);Shenzhen Governmental Sustainable Development Fund(Guangdong,China)(No.KCXFZ20201221173612034);the National Natural Science Foundation of China(China)(No.82170842);the Natural ScienceFoundation of Shenzhen City(China)(No.KCXFZ20201221173600001);Guangdong Basic and Applied Basic Research Foundation(China)(No.2021A1515012164);Shenzhen Key Laboratory of Kidney Diseases(No.ZDSYS20150430161-6234)。

摘　　要：Diabetic nephropathy(DN)has become the leading cause of end-stage renal disease with high morbidity and mortality among individuals with diabetes mellitus.Although functional alterations of renal infiltrating immune cells have been reported as part of the pathological mechanism of DN,the understanding of the immune response underlying peripheral blood mononuclear cells(PBMCs)in DN remains limited.Here,single-cell RNA sequencing(scRNA-seq)was used toprofile the transcriptomic signatures of PBMCs from DN patients.

关 键 词：NEPHROPATHY alterations MORTALITY 

分 类 号：R587.1[医药卫生—内分泌] R692[医药卫生—内科学]