SUV39H1-driven NFATc1 methylation is essential for the c-Cbl-mediated degradation of NFATc1 in an osteoclast lineage  

作　　者：Do-Won Jeong Hye-Jin Kim Jong-Wan Park Seulbee Lee Hyeryeon Jung Eugene C.Yi Nacksung Kime Yang-Sook Chun 

机构地区：[1]Department of Biomedical Sciences,Seoul National University College of Medicine,Seoul 03080,Republic of Korea [2]Department of Physiology,Seoul National University College of Medicine,Seoul 03080,Republic of Korea [3]Ischemic/Hypoxic Disease Institute,Seoul National University College of Medicine,Seoul 03080,Republic of Korea [4]Department of Molecular Medicine and Biopharmaceutical Sciences,Graduate School of Convergence Science and Technology and College of Medicine Or College of Pharmacy,Seoul National University,Seoul 03080,Republic of Korea [5]Department of Pharmacology,Chonnam National University Medical School,Gwangju 61469,Republic of Korea

出　　处：《Genes & Diseases》2024年第4期86-89,共4页基因与疾病（英文）

基　　金：supported by the National Research Foundation of Korea(No.2019R1A2C2083886,2018R1A5A20-25964);supported by the Cooperative Research Program of Basic Medical Science and Clinical Science from Seoul National University College of Medicine(No.800-20220312).

摘　　要：Bone undergoes continuous remodeling by tightly-coordinated actions of bone-resorbing osteoclasts and boneforming osteoblasts.1 Recent studies document that the dysregulation of histone methylation profiles is associated with the progression of osteoclastogenesis.However,the specific epigenetic modifiers are incompletely understood.In this study,we demonstrate an inhibitory role of a variegation 3-9 homolog 1(SUV39H1)in osteoclast formation.

关 键 词：OSTEOCLAST REMODELING INCOMPLETE 

分 类 号：R681[医药卫生—骨科学]