Immunoglobulin superfamily containing leucine-rich repeat(ISLR)negatively regulates osteogenic differentiation through the BMP-Smad signaling pathway  

作　　者：Lei Xiong Miaomiao Lan Chang Liu Lei Li YingYing Yu Tongtong Wang Fan Liu Kun Wang Jin Liu Qingyong Meng 

机构地区：[1]State Key Laboratory of Agrobiotechnology,College of Biological Sciences,China Agricultural University,Beijing 100094,China

出　　处：《Genes & Diseases》2024年第4期138-140,共3页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China(No.31790412,31970712);the National Key Research and Development Program of China(No.2021YFF1000603);earmarked fund for CARS36,the Plan 111(B12008).

摘　　要：Osteoporosis(OP)is an aging-associated condition that significantly affects the quality of life in aging humans and has few treatment options.As an important marker,recombinant immunoglobulin superfamily containing leucinerich repeat(ISLR)could be used as a gene therapy for OP.We herein used alkaline phosphatase(ALP)and alizarin red S(ARS)staining to evaluate osteogenic differentiation potential.

关 键 词：IMMUNOGLOBULIN ALKALINE herein 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]