The key mediator of diabetic kidney disease:Potassium channel dysfunction  

作　　者：Jia Guo Chaojie Zhang Hui Zhao Yufan Yan Zhangsuo Liu 

机构地区：[1]Nephrology Research Center,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450052,China [2]Key Laboratory of Precision Diagnosis and Treatment for Chronic Kidney Disease in Henan Province,Zhengzhou,Henan 450052,China [3]Research Center for Kidney Disease,Zhengzhou,Henan 450052,China

出　　处：《Genes & Diseases》2024年第4期188-200,共13页基因与疾病（英文）

基　　金：supported by the National Natural Science Foundation of China(No.82070745 to J.G.);the Science and Technology Research Project of Henan Province,China(No.202102310051,182102310571to J.G.);the Innovation Scientists and Technicians Troop Construction Projects of Henan Province,China(No.182101510002 to Z.L.).

摘　　要：Diabetic kidney disease is a leading cause of end-stage renal disease,making it a global public health concern.The molecular mechanisms underlying diabetic kidney disease have not been elucidated due to its complex pathogenesis.Thus,exploring these mechanisms from new perspectives is the current focus of research concerning diabetic kidney disease.lon channels are important proteins that maintain the physiological functions of cells and organs.Among ion channels,potassium channels stand out,because they are the most common and important channels on eukaryotic cell surfaces and function as the basis for cell excitability.Certain potassium channel abnormalities have been found to be closely related to diabetic kid-ney disease progression and genetic susceptibility,such as K_(ATP),K_(ca),K_(ir),and K_(v).In this review,we summarized the roles of different types of potassium channels in the occurrence and devel-opment of diabetic kidney disease to discuss whether the development of DKD is due to potas-sium channel dysfunction and present new ideas for the treatment of DKD.

关 键 词：Channel dysfunction Diabetic kidney disease End-stage renal disease lon channel POTASSIUM 

分 类 号：R587.1[医药卫生—内分泌] R692[医药卫生—内科学]