天然及人工合成水凝胶在医用止血敷料上的研究进展  

esearch Advances in Natural and Synthetic Hydrogels for Medical Hemostatic Dressings

作　　者：彭园园 吕丹[1,2] 罗锋 杨奉玲[4] ENG Yuan-yuan;LV Dan;LUO Feng;YANG Feng-ling(Department of Otolaryngology-Head&Neck Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Otolaryngology-Head&Neck Surgery,Huaxi Tumor Hospital,Sichuan University,Chengdu 610041,China;College of Polymer Science and Engineering,Sichuan University,Chengdu 610041,China;Department of Otolaryngology-Facial Plastic Surgery,Mianyang Central Hospital,Mianyang 621000,China)

机构地区：[1]四川大学华西医院耳鼻咽喉头颈外科,成都610041 [2]四川大学华西天府医院耳鼻咽喉头颈外科,成都610041 [3]四川大学高分子科学与工程学院,成都610041 [4]绵阳市中心医院耳鼻咽喉颌面外科,绵阳621000

出　　处：《高分子通报》2024年第6期713-724,共12页Polymer Bulletin

基　　金：四川省科技厅项目(项目号2022YFS0064,2023NSFSC1449);高分子材料工程国家重点实验室自主课题经费资助(项目号sklpme2022-2-07)。

摘　　要：出血事件可严重威胁人类的生命,也给医务人员的诊治工作带来巨大挑战。已有越来越多的止血材料被开发应用,但仍不能完全满足复杂出血状况的止血。水凝胶被成功合成后,它的亲水性和生物相容性引起生物材料学者们的极大兴趣。在过去几十年中,研究人员对水凝胶在止血方面的应用开展了大量的研究。基于此,本文从原材料的角度分类,概述了常见的天然多糖、天然蛋白质及人工合成水凝胶,总结了其原材料的特点、止血相关机制及最新研究进展,并对该领域的发展趋势进行了展望,以期推动水凝胶在止血领域的应用。Hemorrhagic events pose a serious threat to human life and present significant challenges to the diagnostic efforts of healthcare professionals.Despite the increasing development and application of hemostatic materials,they still fall short of fully meeting the complexities of bleeding conditions.With the successful synthesis of hydrogels,their hydrophilic nature and biocompatibility have captured the keen interest of biomaterial scientists.Over the past few decades,researchers have conducted extensive studies on the application of hydrogels in hemostasis.In light of this,this paper categorizes common natural polysaccharides,natural proteins,and artificially synthesized hydrogels from the perspective of raw materials.It provides an overview of their characteristics,hemostatic mechanisms,and recent research advancements.Additionally,the paper offers a prospective analysis of the trends in this field,aiming to drive the application of hydrogels in the domain of hemostasis.

关 键 词：组织黏合剂 组织黏合水凝胶 止血机制 出血模型 生物医学 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]