智能响应材料在生物医用领域的应用与进展  

Smart Responsive Materials in Biomedical Applications and Progress

作　　者：易江南 田珮 向玮琦 王邦奎 吴江渝[1] 曾小平[1] 王大威[1] YI Jiang-nan;TIAN Pei;XIANG Wei-qi;WANG Bang-kui;WU Jiang-yu;ZENG Xiao-ping;WANG Da-wei(School of Materials Science and Engineering,Wuhan Institute of Technology,Wuhan 430205,China)

机构地区：[1]武汉工程大学材料科学与工程学院,武汉430205

出　　处：《高分子通报》2024年第6期725-741,共17页Polymer Bulletin

基　　金：武汉工程大学自然科学基金(基金号21QD47)。

摘　　要：智能响应材料是一类能够响应外部环境微小变化,并通过物理化学过程实现自组装、相变或形态变化的材料,本文重点介绍了智能响应材料对溶液浓度、pH、温度、电磁波(包含红外线、紫外线和可见光)等外部因素变化的响应机理,阐述了微球状、纤维状、膜状与三维网状等微观结构的结构类型与功能特点,并探讨了其在药物释放、医用敷料与靶向治疗等领域的应用,展望了智能响应材料在生物医用领域的发展前景与研究重点。Smart responsive materials are a class of materials that can respond to small changes in the external environment and achieve self-assembly,phase transition or morphology change through physicochemical processes.The mechanisms by which smart-responsive materials respond to changes in external factors such as solution concentration,pH,temperature,and electromagnetic waves(including infrared,ultraviolet,and visible light)are highlighted in this review.The structure and functional characteristics of microstructures such as microspheres,fibers,membranes and three-dimensional meshes are described,and their applications and research prospects in the fields of drug release,medical dressings and targeted therapies are explored.Prospects and research priorities for the development of smart-responsive materials in biomedical applications are outlined.

关 键 词：智能响应材料 响应机理 药物释放 医用敷料 靶向治疗 

分 类 号：R318.08[医药卫生—生物医学工程] TB381[医药卫生—基础医学]