在心力衰竭中RXRα激活上调Ndufs4的转录发挥心脏保护作用  

Activation of RXRa exerts cardioprotection through transcriptional upregulation of Ndufs4 in heart failure

作　　者：邵明燕 李玲孺 马林 宋超 李伟利 张亚雯 成文堃 陈云 杨晔 王倩 李春 王琦 王伟 王勇 Mingyan Shao;Lingru Li;Lin Ma;Chao Song;Weili Li;Yawen Zhang;Wenkun Cheng;Yun Chen;Ye Yang;Qian Wang;Chun Li;Qi Wang;Wei Wang;Yong Wang(Beijing Key Laboratory of Traditional Chinese Medicine Syndrome and Formula,College of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases,Beijing University of Chinese Medicine,Beijing 100029,China;School of Computer/School of Software,University of South China,Hengyang 421001,China;State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China;Beijing Key Laboratory of Traditional Chinese Medicine Syndrome and Formula,Modern Research Center of Traditional Chinese Medicine,School of Traditional Chinese Material Medica,Beijing University of Chinese Medicine,Beijing 100029,China;School of Basic Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510700,China;State Key Laboratory of Traditional Chinese Medicine Syndrome,Guangdong Provincial Key Laboratory of Syndrome and Formula,Guangzhou 510700,China;Yunnan University of Chinese Medicine,Kunming 650500,China)

机构地区：[1]Beijing Key Laboratory of Traditional Chinese Medicine Syndrome and Formula,College of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China [2]National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases,Beijing University of Chinese Medicine,Beijing 100029,China [3]School of Computer/School of Software,University of South China,Hengyang 421001,China [4]State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking University,Beijing 100191,China [5]Beijing Key Laboratory of Traditional Chinese Medicine Syndrome and Formula,Modern Research Center of Traditional Chinese Medicine,School of Traditional Chinese Material Medica,Beijing University of Chinese Medicine,Beijing 100029,China [6]School of Basic Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510700,China [7]State Key Laboratory of Traditional Chinese Medicine Syndrome,Guangdong Provincial Key Laboratory of Syndrome and Formula,Guangzhou 510700,China [8]Yunnan University of Chinese Medicine,Kunming 650500,China

出　　处：《Science Bulletin》2024年第9期1202-1207,共6页科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (82174215, 82230126, 82174364, 82374420,82305025 and 82222075);the Fundamental Research Funds for the Central Universities (Distinguished project);Science and Technology Department of Beijing University of Chinese Medicine(BZY-JMZY-2022-001);“High level Key Discipline of National Administration of Traditional Chinese Medicine-Traditional Chinese Constitutional Medicine (zyyzdxk-2023251)”。

摘　　要：Myocardial infarction-induced heart failure (HF) is the leading cause of mortality and disability worldwide [1]. Studies have established that HF is characterized by impaired mitochondrial energy production [2]. Hence, pharmacological targeting of energy production pathways has emerged as a promising strategy against HF [3]. Retinoid X receptor a (RXRa) is a ligand-activated transcription factor.

关 键 词：IMPAIRED 心脏保护作用 RXRα 

分 类 号：R541.6[医药卫生—心血管疾病]