Supramolecular systems for bioapplications:recent research progress in China  

作　　者：Yue-Yang Liu Xiao-Yong Yu Yu-Chen Pan Hang Yin Shuang Chao Yujie Li He Ma Minzan Zuo Kun-Xu Teng Jun-Li Hou Yong Chen Dong-Sheng Guo Ruibing Wang Yuxin Pei Zhichao Pei Jiang-Fei Xu Xiao-Yu Hu Chunju Li Qing-Zheng Yang Leyong Wang Yu Liu Zhan-Ting Li 

机构地区：[1]State Key Laboratory of Organometallic Chemistry,Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200032,China [2]Department of Chemistry,Fudan University,Shanghai 200438,China [3]College of Chemistry,State Key Laboratory of Elemento-Organic Chemistry,Collaborative Innovation Center of Chemical Science and Engineering,Nankai University,Tianjin 300071,China [4]State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macao,Macao 999078,China [5]College of Chemistry&Pharmacy,Northwest A&F University,Yangling 712100,China [6]Key Lab of Organic Optoelectronics&Molecular Engineering,Department of Chemistry,Tsinghua University,Beijing 100084,China [7]College of Materials Science and Technology,Nanjing University of Aeronautics and Astronautics,Nanjing 211106,China [8]Key Laboratory of Radiopharmaceuticals,Ministry of Education,College of Chemistry,Beijing Normal University,Beijing 100875,China [9]Tianjin Key Laboratory of Structure and Performance for Functional Molecules,College of Chemistry,Tianjin Normal University,Tianjin 300387,China [10]State Key Laboratory of Analytical Chemistry for Life Science,Jiangsu Key Laboratory of Advanced Organic Materials,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing 210023,China

出　　处：《Science China Chemistry》2024年第5期1397-1441,共45页中国科学（化学英文版）

摘　　要：Supramolecular systems feature dynamic,reversible and stimuli-responsive characteristics,which are not easily achieved by molecular entities.The last decade has witnessed tremendous advances in the investigations of supramolecular systems for various bioapplications,which include drug delivery,anticancer therapy,antibacterial therapy,photodynamic therapy,photothermal therapy,combination therapy,antidotes for residual drugs or toxins,and bioimaging and biosensing.Host-guest chemistry has played a key role in the development of such bioactive supramolecular systems,and natural macrocycles(such as cyclodextrins),synthetic macrocycles(such as calixarenes,cucurbit[n]urils,and pillararenes),and porous framework polymers(such as supramolecular organic frameworks and flexible organic frameworks)have been most successfully used as hosts to build different kinds of host-guest systems for attaining designed biofunctions.The self-assembly of rationally designed amphiphilic molecules,macromolecules and polymers represent another important approach for the construction of supramolecular architectures with advanced biofunctions.In this review,we summarize the important contributions made by Chinese researchers in this field,with emphasis on those reported in the past five years.

关 键 词：host-guest chemistry drug delivery anticancer and antibacterial photodynamic therapy photothermal therapy ANTIDOTE transmembrane channel bioimaging and biosensing 

分 类 号：O641.3[理学—物理化学]