Nickel-catalyzed carbonylative four-component 1,4-dicarbofunctionalization of 1,3-enynes  

作　　者：Yan Zhao Qi-Chao Shan Hong Xin Pin Gao Xu Yang Xin-Hua Duan Li-Na Guo 

机构地区：[1]Department of Chemistry,School of Chemistry,Xi’an Key Laboratory of Sustainable Energy Material Chemistry and Engineering Research Center of Energy Storage,Materials and Devices,Ministry of Education,Xi’an Jiaotong University,Xi’an,710049,China [2]School of Electrical Engineering,Xi’an Jiaotong University,Xi’an,710049,China

出　　处：《Science China Chemistry》2024年第6期2029-2038,共10页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(22171220,21971201);the Fundamental Research Funds of the Central Universities(xtr072022003)。

摘　　要：An efficient Ni-catalyzed four-component 1,4-carbocarbonylation of 1,3-enynes with activated alkyl halides and arylboronic acids under atmospheric pressure of CO is presented.By tuning the electronic and steric effects of alkyl radicals,both electronrich and electron-deficient 1,3-enynes were compatible with this cascade.This protocol features mild conditions,broad substrate scope,excellent functional group compatibility and facile gram-scale synthesis,providing a practical approach to the quaternary carbon center-containing allenyl ketones.Mechanistic study revealed that the acyl-NiIIspecies plays an important role in both the coupling and the alkyl radical generation processes.

关 键 词：Ni catalysis four-component 1 4-carbocarbonylation 1 3-enynes 

分 类 号：TQ224.23[化学工程—有机化工] O643.36[理学—物理化学]