Aggregation-induced T_(1)/T_(2) contrast enhancement for magnetic resonance imaging-guided intraoperative surgery  

作　　者：Wenbo Sun Bin Yu Dianshuai Huang Chunhuan Jiang Wei Wang Jianhua Liu Zonghua Wang Lehui Lu 

机构地区：[1]State Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences,Changchun,130022,China [2]College of Chemistry and Chemical Engineering,Shandong Sino-Japanese Center for Collaborative Research of Carbon Nanomaterials,Qingdao Application Technology Innovation Center of Photoelectric Biosensing for Clinical Diagnosis and Treatment,Qingdao University,Qingdao,266071,China [3]Department of Radiology,Second Hospital of Jilin University,Changchun,130041,China

出　　处：《Science China Chemistry》2024年第6期2046-2055,共10页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(22134006,21721003,22204161,U2241287);the Natural Science Foundation of Shandong Province(ZR2020MB063);the Program of Science and Technology Development Plan of Jilin Province(20230101039JC)。

摘　　要：Magnetic resonance imaging(MRI)plays an important role in precision medicine that is hampered by the lack of contrast agents with high efficiency and the ability to translate diagnostic accuracy into therapeutic intervention.Herein,we demonstrate a DNA-based MRI probe that overcomes previous single-mode enhancement and provides a mechanism of action for aggregationinduced dual-modal MRI signal enhancement.A facile method is developed to produce aggregated T_(1)/T_(2)dual-modal NaGdF_(4):Dy@PDA-DNA(PDA=polydopamine)MRI probes.When aggregated,this probe can further amplify MRI signal intensity and exhibit improved geometrical and positional stability in vivo.The performance of the NaGdF_(4):Dy@PDA-DNA MRI probe toward MRI-guided preoperative planning and visualization-guided surgery is verified using an orthotopic tumor-bearing mouse model.The result shows that the rapid metabolism of the degraded probe leads to the mitigation of long-term toxic effects.Therefore,the developed high-performance MRI probe is of great significance for enhancing MRI diagnostic accuracy into precision medical therapeutic interventions.

关 键 词：MRI probe DNA aggregation-induced T_(1)/T_(2)contrast enhancement precision medicine degradable probe 

分 类 号：R445.2[医药卫生—影像医学与核医学] O657.2[医药卫生—诊断学]