Accelerated heterogenous ring-opening polymerization towards well-defined helical poly(N-allyl alanine)with clickable side chains  

作　　者：Anyao Ma Xin Wang Sunting Xuan Zhengbiao Zhang 

机构地区：[1]College of Chemistry,Chemical Engineering and Materials Science,Soochow University,Suzhou,215123,China [2]State Key Laboratory of Radiation Medicine and Protection,Soochow University,Suzhou,215123,China

出　　处：《Science China Chemistry》2024年第6期2056-2062,共7页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(22201197,21925107);the Collaborative Innovation Center of Suzhou Nano Science and Technology,National Key R&D Program of China(2022YFB3704900);the Natural Science Foundation of Jiangsu Province(BK20220507);the Natural Science Foundation of Jiangsu Higher Education Institutions(21KJB150035)。

摘　　要：Well-defined poly(N-allyl alanine)has been synthesized by heterogenous ring-opening polymerization(HROP)of less reactive N-allyl-alanine N-carboxyanhydride,using acetic acid as the catalyst and benzylamine as the initiator,in non-polar n-hexane.Interestingly,the polymerization exhibited typical features of living polymerization though both monomer(liquid)and polymer(solid)have minimal solubility in n-hexane.The obtained polymer showed a stable helix structure independent of the temperatures screened,as evidenced by circular dichroism analysis.Also,the preliminary study demonstrated that the side chains can be post-functionalized through thiol-ene click chemistry with quantitative conversion.Together,this work provides guidance for the development of accelerated HROP of other liquid monomers bearing low reactivity.Besides,the helical and functionalizable poly(N-allyl alanine)could be a useful“clickable platform”for the design of variable biomaterials via efficient click chemistry.

关 键 词：heterogenous ring-opening polymerization controlled polymerization stable helix clickable N-substituted polypeptide di-substituted polypeptoid 

分 类 号：TQ316.341[化学工程—高聚物工业]