Exploring the impact of pericentric inversion of chromosome 9 on fertility in sperm donors  

作　　者：Qian Liu Wen-Jun Zhou Zeng-Hui Huang Xiu-Hai Huang Jian Wu Xi-Ren Ji Xue-Feng Luo Yu-Ling Tang Rui-Jun Wang Li-Qing Fan Chuan Huang Wen-Bing Zhu 

机构地区：[1]Institute of Reproductive and Stem Cell Engineering,Basic Medicine College,Central South University,Changsha 410013,China [2]Clinical Research Center for Reproduction and Genetics in Hunan Province,Reproductive and Genetic Hospital of CITIC-Xiangya,Changsha 410005,China

出　　处：《Asian Journal of Andrology》2024年第3期302-307,共6页亚洲男性学杂志（英文版）

基　　金：financial supported by National Natural Science Foundationof China(No.82001634);the China Postdoctoral Science Foundation(No.2019M661521).

摘　　要：Pericentric inversion of chromosome 9(inv[9])is a common chromosomal structural variant,but its impact on clinical outcomesremains debated.The screening criteria of sperm banks are rarely mentioned to individuals with inv(9).In this study,we evaluatedthe fertility of sperm donors with inv(9)who met eligibility criteria for sperm banks(inv[9]-eligible donors).From March 2004 toMay 2022,chromosomal analysis of 16124 sperm donors at CITIC-Xiangya Human Sperm Bank in Hunan Province(Changsha,China)found that 251(1.6%)had chromosome variations,with inv(9)being the most prevalent at 1.1%.All 169 inv(9)-eligibledonors were contacted to collect fertility outcome data,along with 206 eligible donors without inv(9)as controls.In addition,semen samples from inv(9)-eligible donors and eligible donors underwent assessments of sperm fluorescence in situ hybridization(FISH),mitochondrial membrane potential,DNA fragmentation index,acrosome integrity,reactive oxygen species(ROS),andsperm morphology.Results showed that inv(9)did not significantly increase reproductive risks overall.Despite detecting ROSlevel differences,the clinical impact may be insignificant.This study provides new data on the inv(9)population that can serveas a valuable reference for decision-making by sperm banks as well as for genetic counseling and clinical guidance for individualscarrying inv(9)variant.

关 键 词：male fertility pericentric inversion of chromosome 9 sperm bank sperm functional parameters 

分 类 号：R698.2[医药卫生—泌尿科学]