甘油三酯-葡萄糖指数与内脏脂肪面积联合检测对2型糖尿病早期外周血管病变的预测价值  

Predictive value of combined detection of triglyceride glucose index and visceral fat area in the diagnosis of early peripheral vascular disease in type 2 diabetes mellitus

作　　者：卢新妍 林萱 崔静[1] 王强[3] 郭红艳 邓春霞 徐嘉蔚 丁家豪 占水朦 夏芳 LU Xinyan;LIN X uan;CUI Jing;WANG Qiang;GUO Hongyan;DENG Chunxia;XU Jiawei;DING Jiahao;ZHAN Shuimeng;XIA Fang(Dept.of Endocrinology,CR&WISCO General Hospital Affiliated to Wuhan University of Science and Technology,Wuhan 430080,Hubei,China;Medical College,Wuhan University of Science and Technology,Wuhan 430062,Hubei,China;Institute of Infection,Immunology and Tumor Microenvironment,Hubei Province Key Laboratory of Occupational Hazard Identification and Control,School of Medicine&Wuhan University of Science and Technology,Wuhan 430065,Hubei,China;Dept.of Endocrinology,The People's Hospital of Guangxi Zhuang Autonomous Region,Nanning,530021,Guangxi,China)

机构地区：[1]武汉科技大学附属华润武钢总医院内分泌科,湖北武汉430080 [2]武汉科技大学医学院,湖北武汉430062 [3]武汉科技大学医学院湖北省职业病危害识别与控制重点实验室感染免疫与肿瘤微环境研究所,湖北武汉430065 [4]广西壮族自治区人民医院内分泌科,广西南宁530021

出　　处：《武汉大学学报（医学版）》2024年第5期582-588,共7页Medical Journal of Wuhan University

基　　金：湖北省微循环学会人才培养专项科研基金资助项目(编号:HBWXH2018(1)‑6)。

摘　　要：目的:探讨甘油三酯‑葡萄糖指数(TyG)、内脏脂肪面积(VFA)对2型糖尿病(T2DM)患者发生早期外周血管病变(PVD)的预测价值。方法:回顾性分析符合纳入标准437例T2DM患者,根据是否合并外周血管病变将患者分为T2DM合并PVD患者和T2DM无PVD患者。使用多因素Logistic回归分析比较两组间指标的差异,采用受试者工作特征(ROC)曲线评估TyG、VFA以及TyG+VFA联合诊断对T2DM早期PVD的预测价值。结果:排除混杂因素干扰后,多因素Logistic回归分析结果显示:VFA和TyG指数是影响T2DM PVD的独立危险因素(P<0.05)。ROC曲线分析显示,TyG+VFA联合诊断的ROC曲线下面积最大,为0.863,诊断价值更大。结论:TyG、VFA与T2DM早期PVD的发生密切相关,二者联合诊断可提高预测价值。Objective:To explore the predictive value of the triglyceride‑glucose index(TyG)and visceral fat area(VFA)in early peripheral vascular disease(PVD)in patients with type 2 diabetes mellitus(T2DM).Methods:A retrospective analysis was conducted on 437 T2DM patients who met the inclusion criteria.Patients were divided into T2DM patients with PVD and T2DM patients without PVD.Multiple logistic regression analysis was used to compare the differences in indicators between the two groups,and receiver operating characteristic(ROC)curves were used to evaluate the predictive value of TyG,VFA,and TyG+VFA combined diagnosis for early PVD in T2DM.Results:After excluding confounding factors,multivariate logistic regression analysis showed that VFA and TyG indexes were independent risk factors for PVD in T2DM(P<0.05).ROC curve analysis showed that the combined diagnosis of TyG+VFA had the largest area under the ROC curve,which was 0.863,indicating a greater diagnostic value.Conclusion:TyG and VFA are closely related to the occurrence of early PVD in T2DM,and their combined diagnosis can improve the predictive value.

关 键 词：外周血管疾病 2型糖尿病 甘油三酯‑葡萄糖指数 内脏脂肪 

分 类 号：R587.1[医药卫生—内分泌]