酸藤子的化学成分研究  

Chemical constituents of Embelia laeta

作　　者：李婉亭 李志强[1] 曾祥昊 余惠敏 钟国跃[1,2] 冯育林 何明珍[1,2] LI Wanting;LI Zhiqiang;ZENG Xianghao;YU Huimin;ZHONG Guoyue;FENG Yulin;HE Mingzhen(Jiangxi University of Chinese Medicine,Nanchang 330006,China;National Engineering Research Center for Manufacturing Technology of Chinese Medicine Solid Preparation,Nanchang 330006,China)

机构地区：[1]江西中医药大学,江西南昌330006 [2]中药固体制剂制造技术国家工程研究中心,江西南昌330006

出　　处：《中草药》2024年第9期2868-2874,共7页Chinese Traditional and Herbal Drugs

基　　金：国家重点研发计划课题(2019YFC1712302);国家重点研发计划课题(2019YFC1712304);中央引导地方科技发展专项项目(20221ZDD02007);江西中医药大学科技创新团队(CXTD22001)。

摘　　要：目的研究酸藤子Embelia laeta的化学成分。方法利用硅胶、Sephadex LH-20、HP-20大孔吸附树脂、半制备高效液相等各种方法进行分离纯化,通过核磁共振波谱、质谱等对化合物的结构进行表征和解析。结果从酸藤子70%乙醇提取物的正丁醇萃取部位中分离得到19个化合物,分别鉴定为淫羊藿次苷D2(1)、山柰酚-3-O-β-D-葡萄糖-7-O-α-L-鼠李糖苷(2)、反式对羟基桂皮酸(3)、咖啡酸(4)、槲皮素-3-O-α-L-鼠李糖吡喃糖基-7-O-β-D-吡喃葡萄糖苷(5)、4-(β-吡喃葡萄糖基氧基)-苯甲醛(6)、1-O-对羟基肉桂酰单甘油酯(7)、山柰酚-3-O-β-D-(2''-O-β-D-呋喃糖基)-吡喃葡萄糖苷-7-O-α-L-鼠李糖吡喃糖苷(8)、绿原酸(9)、反式咖啡酸(10)、对羟基肉桂酸甲酯(11)、反式-3-O-香豆酰奎宁酸(12)、5-对反式香豆酰奎宁酸甲酯(13)、1-(3',4'-二羟基肉桂酰基)-环戊二烯二醇(14)、槲皮素-3-O-β-D-呋喃芹糖-(1→2)-β-D-吡喃葡萄糖-7-O-α-L吡喃鼠李糖苷(15)、槲皮素-3-O-吡喃葡萄糖苷(16)、柽柳黄素3-O-β-D-葡萄糖苷-7-O-α-L-鼠李糖苷(17)、N-(3-((3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)丙基)肉桂酰胺(18)、D-去氢南天竹啡碱(19)。结论其中化合物18为新化合物,命名为酸藤子碱苷,化合物1~3、5~8、11~15、17和19首次从酸藤子植物中分离得到。Objective To study the chemical constituents from Embelia laeta.Methods The compounds were separated and purified by various methods such as silica gel,Sephadex LH-20,HP-20 macroporous resin adsorption,semi-preparative high-performance liquid phase,and the structure of the compounds were identified and analyzed by nuclear magnetic resonance spectrometry and mass spectrometry.Results A total of nineteen compounds were isolated from the n-butanol extraction site of 70%ethanol extract of E.laeta and identified as icariside D2(1),kaempferol-3-O-β-D-glucose-7-O-α-L-rhamnoside(2),trans-hydroxycinnamic acid(3),caffeic acid(4),quercetin-3-O-α-L-rhamnopyranosyl-7-O-β-D-glucopyranoside(5),4-(β-glucopyranosyloxy)-benzaldehyde(6),1-O-phydroxycinnamalyl monoglycerides(7),kaempferol-3-O-β-D-(2''-O-β-D-apiofuranosyl)-glucopyranoside-7-O-α-L-rhamnopyranoside(8),chlorogenic acid(9),trans-caffeic acid(10),methyl-p-coumarate(11),trans-3-O-coumaroylquinic acid(12),methyl 5-transcoumarylquinic acid(13),1-(3',4'-dihydroxycinnamoyl)-cyclopenta-2,5-diol(14),quercetin-3-O-β-D-furano-celery-(1→2)-β-Dglucopyranos-7-O-α-L-rhamnopyranoside(15),quercetin-3-O-glucopyranoside(16),tamarixetin 3-O-β-D-glucoside-7-O-α-Lrhamnoside(17),N-(3-((3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)propyl)cinnamamide(18),D-dehydronantenine(19).Conclusion Among them,compound 18 is a new compound,named embelia alkali glycoside,and compounds 1—3,5—8,11—15,17 and 19 were isolated from E.laeta for the first time.

关 键 词：酸藤子 淫羊藿次苷D2 反式对羟基桂皮酸 槲皮素-3-O-α-L-鼠李糖吡喃糖基-7-O-β-D-吡喃葡萄糖苷 D-去氢南天竹啡碱 

分 类 号：R284.1[医药卫生—中药学]