五味子非药用部位活性成分和药理作用研究进展  

Research progress on active components and pharmacological effects of nonmedicinal parts of Schisandra chinensis

作　　者：刘继艳 王冰[2,5] 李超宇 于淼 LIU Jiyan;WANG Bing;LI Chaoyu;YU Miao(Engineering Research Center for Medicine,Harbin University of Commerce,Harbin 150076,China;School of Food Engineering,Harbin University of Commerce,Harbin 150076,China;Engineering Research Center of Natural Anti-tumor Drugs,Ministry of Education,Harbin 150076,China;Heilongjiang Provincial Key Laboratory of Cancer Prophylaxis and Anticancer Drugs Research,Harbin 150076,China;Postdoctoral Programme of Meteria Medica Institute of Harbin University of Commerce,Harbin 150076,China)

机构地区：[1]哈尔滨商业大学药物工程技术研究中心,黑龙江哈尔滨150076 [2]哈尔滨商业大学食品工程学院,黑龙江哈尔滨150076 [3]国家教育部抗肿瘤天然药物工程研究中心,黑龙江哈尔滨150076 [4]黑龙江省肿瘤预防与抗肿瘤药物研究重点实验室,黑龙江哈尔滨150076 [5]哈尔滨商业大学药物研究所博士后科研工作站,黑龙江哈尔滨150076

出　　处：《中草药》2024年第9期3179-3189,共11页Chinese Traditional and Herbal Drugs

基　　金：黑龙江省重点研发计划项目(2022ZX02C07);黑龙江省优秀青年教师基础研究支持计划(YQJH2023243)。

摘　　要：五味子Schisandra chinensis始载于《神农本草经》,具有收敛固涩、益气生津、补肾宁心的功效。在《中国药典》2020年版中规定五味子的药用部位是干燥成熟果实,含有木脂素、多糖、萜类及黄酮等化合物,具有调节中枢神经系统和内分泌系统、抗肿瘤、抗氧化、抗炎、抑菌等作用。近年来研究显示五味子藤茎、叶、果梗和根等非药用部位同样含有木脂素、多糖、萜类及黄酮等活性成分,其中一些活性成分含量高于药用部位,但非药用部位常作为杂质被废弃,不仅未得到充分利用还造成资源浪费。基于已公开发表的文献,对五味子非药用部位的活性成分和药理作用进行总结,为深入开发五味子非药用部位提供参考和数据支撑,为五味子非药用部位的综合利用打下基础。Schisandra chinensis(Turcz.)Baill was first recorded in Shennong Bencao Jing(Divine Farmer’s Materia Medica),classified as a top-grade herb.It is known for its astringent,qi-enhancing,fluid-producing,kidney-nourishing,and mind-calming effects.In the 2020 edition of Chinese Pharmacopoeia,the medicinal part of S.chinensis is defined as its dry and ripe fruit,which contains compounds such as lignin,polysaccharides,terpenes,and flavonoids.These compounds contribute to its regulating the central nervous system and endocrine system,antitumor,anti-oxidative,anti-inflammatory,and antibacterial effects.Recent research has shown that non-medicinal parts of S.chinensis,including the vine stems,leaves,fruit stems,and roots,also contain active ingredients like lignin,polysaccharides,terpenes,and flavonoids.Some of these active components are even more concentrated than in the medicinal parts.However,these non-medicinal parts are often discarded as impurities,leading to resource wastage and underutilization.This paper summarizes the active components and pharmacological actions of the non-medicinal parts of S.chinensis based on published literature,providing references and data support for further development of non-medicinal parts of S.chinensis and laying the foundation for comprehensive utilization of non-medicinal parts of S.chinensis.

关 键 词：五味子 非药用部位 木脂素 多糖 中枢神经系统 抗肿瘤 抗氧化 

分 类 号：R282.71[医药卫生—中药学]