基于基准关联度和熵权-优劣解距离法综合评价优选经典名方羌活胜湿汤提取工艺  

Optimization of extraction process for classical prescription Qianghuo Shengshi Decoction based on standard relation and entropy weight-TOPSIS method

作　　者：郑文烈 张强 冯飞 吴婉芬 张雯[1,2] 谢辉 王洪兰[1,2] 赵晓莉 狄留庆[1,2] ZHENG Wenlie;ZHANG Qiang;FENG Fei;WU Wanfen;ZHANG Wen;XIE Hui;WANG Honglan;ZHAO Xiaoli;DI Liuqing(School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210023,China;Jiangsu Engineering Research Center for Efficient Delivery System of Traditional Chinese Medicine,Nanjing 210023,China;Jiangsu Chiatai Qingjiang Pharmaceutical Co.,Ltd.,Huaian 223001,China)

机构地区：[1]南京中医药大学药学院,江苏南京210023 [2]江苏省中药高效给药系统工程技术研究中心,江苏南京210023 [3]江苏正大清江制药有限公司,江苏淮安223001

出　　处：《中草药》2024年第10期3310-3320,共11页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金项目(82074024);国家自然科学基金项目(82104688)。

摘　　要：目的应用正交试验设计并结合基准关联度和熵权-优劣解距离(technique for order preference by similarity to an ideal solution,TOPSIS)模型筛选羌活胜湿汤现代提取工艺。方法以加水倍数、提取时间、提取次数为考察因素进行正交试验设计制备9份样品,以样品中升麻素苷、阿魏酸、甘草苷、5-O-甲基维斯阿米醇苷、甘草酸、羌活醇、蛇床子素、二氢欧山芹醇当归酸酯含量和指纹图谱相似度以及干膏率作为评价指标,计算各样品指标基准关联度,用于熵权法计算以确定各指标所占权重,计算综合评分,采用TOPSIS模型计算样品与基准样品的相对接近度,并进行排序,结合综合评分筛选最佳提取工艺。结果通过熵权-TOPSIS模型确定最佳提取工艺为加10倍水,提取2次,每次提取30 min,3批验证样品综合评分均值为85.53%,RSD值为1.74%,工艺稳定可行。结论结合基准关联度和熵权-TOPSIS模型的综合策略可用于优选经典名方现代提取工艺,且工艺稳定可靠,该策略可为其他经典名方制剂研究提供参考。Objective To apply orthogonal experimental design and combine the standard relation and entropy weight-technique for order preference by similarity to an ideal solution(TOPSIS)model to screen the modern extraction process of Qianghuo Shengshi Decoction(羌活胜湿汤,QSD).Methods Nine samples were prepared by orthogonal experimental design with the amount of water,extraction time and frequency as the investigating factors,and the contents of prim-O-glucosylcimifugin,ferulic acid,liquiritin,5-Omethylvisammioside,glycyrrhizic acid,notopterol,osthole,columbianadin,and fingerprint similarity,as well as the dry paste rate of the samples,were taken as the evaluating indexes to calculate the standard relation of each sample index,and then used in entropy weighting to determine the weights of the indexes to calculate the composite scores,and then calculated and ranked by the relative proximity of the samples with the standard sample by using the TOPSIS model to screen for the optimal extraction process combined with the composite scores.Results The optimal extraction process was determined by the entropy weight-TOPSIS model by adding 10 times water and extracting twice for 30 min each time,the mean value of the combined score of the three batches of validation samples was 85.53%,the RSD value was 1.74%,and the process was stable and feasible.Conclusion An integrated strategy combining standard relation and entropy weight-TOPSIS model can be used to optimize the modern extraction process of classical prescriptions with a stable and reliable process,and this strategy can be used as a reference for the research of other classical prescriptions.

关 键 词：羌活胜湿汤 基准关联度 熵权法-TOPSIS模型 提取工艺 升麻素苷 阿魏酸 甘草苷 5-O-甲基维斯阿米醇苷 甘草酸 羌活醇 蛇床子素 二氢欧山芹醇当归酸酯 指纹图谱 

分 类 号：R283.6[医药卫生—中药学]