中药治疗鼻炎作用机制研究进展  

Research progress on acting mechanism of traditional Chinese medicine intreatment of allergic rhinitis

作　　者：方琦 吴威 戴思思 李红艳[1] 陈智慧[1] 杨关林[1] 张会永[3] FANG Qi;WU Wei;DAI Sisi;LI Hongyan;CHEN Zhihui;YANG Guanlin;ZHANG Huiyong(Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Zhuhai College of Science and Technology,Zhuhai 519041,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]辽宁中医药大学、中医藏象理论及应用国家教育部重点实验室,辽宁沈阳110847 [2]珠海科技学院,广东珠海519041 [3]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中草药》2024年第10期3506-3515,共10页Chinese Traditional and Herbal Drugs

基　　金：广东省自然科学基金项目(2021A1515011485);辽宁省自然科学基金资助项目(2022-NLTS-13-05);沈阳市中青年科技创新人才培育专项(RC230077);沈阳市中青年科技创新人才支持计划项目(RC190281)。

摘　　要：鼻炎是一种临床常见的鼻黏膜炎性疾病,其迁延难愈、反复发作,严重影响人们的生活质量。目前鼻炎治疗主要以化学药为主,具有治标不治本、不良反应多的局限性,因此寻找安全有效的治疗方法迫在眉睫。中医临床治疗鼻炎疗效显著,具有多靶点、多通路、可逆转的优势。目前相关实验研究多在啮齿类动物模型中开展,因此,在对常见鼻炎动物模型的造模方法进行深入研究和总结基础上,对中药复方、中药单味药及中药活性成分治疗鼻炎的研究情况进行梳理和分析,为中医药治疗鼻炎的临床及科研工作提供理论参考。Allergic rhinitis,a common inflammatory disease of the nasal mucosa in clinic,is difficult to be cured and recurrent repeatedly,severely affecting people’s quality of life.At present,allergic rhinitis is mainly treated with western medicine,which treats symptoms rather than root causes and has many adverse reactions.Therefore,it is urgent to find a safe and effective treatment method.The clinical treatment of allergic rhinitis in traditional Chinese medicine(TCM)has remarkable efficacy,with the advantages of multitarget,multi-pathway and reversibility.Currently,most of the relevant experimental studies are carried out in rodent models.Based on the in-depth study and summary of the modeling methods of common allergic rhinitis animal models,this paper sorts and analyzes on the treatment of allergic rhinitis with herbal compounds,single herbs and active ingredients of herbs in recent years,which can provided theoretical references to clinical and scientific research on the treatment of allergic rhinitis with TCM.

关 键 词：鼻炎 动物模型 核因子-κB通路 丝裂原活化蛋白激酶通路 Janus激酶/信号转导与转录激活因子通路 胸腺基质淋巴细胞生成素/OX40配体通路 

分 类 号：R285[医药卫生—中药学]