补骨脂抗肿瘤作用机制研究进展  

Research progress on antitumor mechanism of Psoraleae Fructus

作　　者：刘改廷 勾文峰 许飞飞 郭江红[2] 王跃飞[1] 李祎亮[2] 侯文彬 LIU Gaiting;GOU Wenfeng;XU Feifei;GUO Jianghong;Wang Yuefei;LI Yiliang;HOU Wenbin(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine,Peking Union Medical College&Institute of Radiation Medicine Chinese Academy of Medical Sciences,Tianjin 300192,China)

机构地区：[1]天津中医药大学,天津301617 [2]北京协和医学院&中国医学科学院放射医学研究所,天津市放射医学与分子核医学重点实验室,天津300192

出　　处：《中草药》2024年第10期3529-3538,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(82202950);中央高校基本科研业务费专项资金(3332022063);中国医学科学院医学与健康科技创新工程重大协同创新项目资助(2021-I2M-1-042)。

摘　　要：补骨脂Psoraleae Fructus具有温肾助阳、纳气平喘、温脾止泻等功能,常用于心血管疾病、肾炎、骨质疏松症、癌症和白斑病等的治疗。现代研究表明,补骨脂中主要含有香豆素类、黄酮类、单萜酚类等多种化合物,其中含有多种抗肿瘤活性成分,包括补骨脂素、补骨脂定、补骨脂二氢黄酮、补骨脂二氢黄酮甲醚、补骨脂查耳酮和补骨脂酚等。对乳腺癌、肝癌、肺癌、胃癌、结肠癌及前列腺癌等恶性肿瘤细胞具有较好的增殖抑制作用,其作用机制主要包括增殖凋亡、周期阻滞、氧化应激、多药耐药、自噬、迁移和侵袭。通过对补骨脂中活性成分抗肿瘤的作用机制进行综述,探讨其抗肿瘤研究现状及其开发应用前景,为补骨脂抗肿瘤的研究与发展提供有用的信息。Buguzhi(Psoraleae Fructus)has various functions,including warming the kidneys and assisting with yang,nourishing qi,calming asthma,warming the spleen,and stopping diarrhea.It is commonly used in the treatment of cardiovascular diseases,nephritis,osteoporosis,cancer,and leukoplakia.Recent research indicates that Psoraleae Fructus contains coumarins,flavonoids,monoterpene phenols,and other compounds.These compounds contain various antitumor active ingredients,including psoralen,psoralidin,bavachin,bavachinin,bakuchalcone and bakuchiol.Psoraleae Fructus has been found to inhibit the proliferation of malignant tumor cells such as breast cancer,liver cancer,lung cancer,gastric cancer,colon cancer,and prostate cancer.The mechanism of action of psoraleae mainly involves proliferation and apoptosis,cycle blockade,oxidative stress,multidrug resistance,autophagy,migration,and invasion.This article reviews the antitumor mechanism of action of the active ingredients in Psoraleae Fructus and explores the current status of their antitumor research and their development and application prospects.The aim is to provide useful information for the research and development of psoraleae in antitumor research.

关 键 词：补骨脂 抗肿瘤 增殖凋亡 氧化应激 周期阻滞 多药耐药 补骨脂素 补骨脂定 补骨脂二氢黄酮 

分 类 号：R285[医药卫生—中药学]