理气药抗抑郁作用及机制研究进展  

Research progress on anti-depression effect and mechanism of qi-regulating drugs

作　　者：刘日群 李字棋 肖淑华 郑琴 钟钰 胡国婷 胡鹏翼 LIU Riqun;LI Ziqi;XIAO Shuhua;ZHENG Qin;ZHONG Yu;HU Guoting;HU Pengyi(Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004

出　　处：《中草药》2024年第10期3558-3568,共11页Chinese Traditional and Herbal Drugs

基　　金：江西省中医药管理局科研计划项目(2022Z024)。

摘　　要：抑郁症属于神经精神障碍性疾病,患病人数呈现逐年递增,但发病机制复杂多样且尚未明确。目前临床治疗抑郁症的化学药存在疗效慢、易复发、周期长、不良反应多等缺点。如何有效改善抑郁症的治疗效果成为亟待解决问题。在中医理论指导下,以“疏肝解郁、行气解郁”为治则,发现理气类药对于抑郁症的治疗具有明显优势,发展前景广阔。通过查阅近年理气药论治抑郁症的相关实验研究,从理气药的提取物及活性成分2个方面进行研究总结,客观阐述理气药治疗抑郁症的研究进展,为抑郁症的治疗提供新思路。Depression is a neuropsychiatric disorder,and the number of patients is increasing year by year,but the pathogenesis is complex and unclear.At present,the chemical drugs for clinical treatment of depression have slow efficacy,easy recurrence,long cycle and many side effects.How to effectively improve the therapeutic effect of depression has become an urgent problem to be solved.Based on the guidance of traditional Chinese medicine theory,with“soothing liver and relieving depression,promoting qi and relieving depression”as the treatment principle,it is found that qi-regulating drugs have obvious advantages in the treatment of depression and have broad development prospects.By consulting the relevant experimental studies on treatment of depression with qi-regulating drugs in recent years,this paper summarizes the research progress of qi-regulating drugs in treatment of depression from two aspects of the extract and active components of qi-regulating drugs,in order to provide new ideas for treatment of depression.

关 键 词：抑郁症 理气药 挥发油类(萜类) 黄酮类 香豆素 陈皮 佛手 

分 类 号：R285[医药卫生—中药学]