ATP6AP1 was Phast-ID’ed as a long-sought GEF for Rheb  

作　　者：Song Li Xinxing Ouyang Bing Su 

机构地区：[1]Shanghai Institute of Immunology,Department of Immunology and Microbiology at Basic Medical College,Shanghai Jiao Tong University School of Medicine,Shanghai,China [2]Shanghai Chest Hospital affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China [3]Department of Gastroenterology and Center for Immune-Related Diseases Research at Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,China [4]Shanghai Jiao Tong University School of Medicine-Yale Institute for Immune Metabolism,Shanghai Jiao Tong University School of Medicine,Shanghai,China

出　　处：《Cell Research》2024年第6期397-398,共2页细胞研究（英文版）

摘　　要：A new study from Feng et al.developed an improved proximity labeling technology called PhastID and successfully identified the lysosomal v-ATPase subunit ATP6AP1 as an unconventional guanine nucleotide exchange factor for Rheb,a key positive regulator of mTORC1.ATP6AP1 binds directly to Rheb via a highly conserved C-terminal segment to promote its GTP loading and mTORC1 activation.

关 键 词：PROXIMITY activation CONSERVED 

分 类 号：O62[理学—有机化学]