巴戟天寡糖抗抑郁作用研究进展  

Research Progress on the Antidepressant Effect of Morinda officinalis Oligosaccharides

作　　者：宋咏哲 赵健 叶潇 于敏[3] 吴笑如 马贝贝 王婷婷 杨海润[4] 刘万卉[1] 耿兴超[3] 左泽平 刘颖[3] SONG Yongzhe;ZHAO Jian;YE Xiao;YU Min;WU Xiaoru;MA Beibei;WANG Tingting;YANG Hairun;LIU Wanhui;GENG Xingchao;ZUO Zeping;LIU Ying(Yantai University,Yantai 264003,China;Center for Information,National Medical Products Administraiton,Beijing 100032,China;National Institutes for Food and Drug Control,Beijing 102629,China;Scientific Research Institute,Beijing Tongrentang Co.,Ltd.,Beijing 100079,China)

机构地区：[1]烟台大学,山东烟台264003 [2]国家药品监督管理局信息中心,北京100032 [3]中国食品药品检定研究院,北京102629 [4]北京同仁堂股份有限公司科学研究所,北京100079

出　　处：《中国药学杂志》2024年第10期872-878,共7页Chinese Pharmaceutical Journal

摘　　要：巴戟天是我国传统的“四大南药”之一。现代医学研究发现,巴戟天中含有多种活性成分,如糖类、蒽醌类、环烯醚萜类及氨基酸类等,具有明显提高机体免疫力、增强记忆、抗氧化、抗衰老等作用。其中寡糖类成分表现出良好的抗抑郁活性,这一研究对发展新型抗抑郁药物提供了重要的思路与方向。在我国,以巴戟天寡糖为主要成分的巴戟天寡糖胶囊已获批上市,成为我国具有独立知识产权的中药五类抗抑郁症新药。为了更好地推进巴戟天寡糖的研究,本文全面梳理和归纳了国内外关于巴戟天寡糖的相关文献,对其研发历程、抗抑郁作用机制、提取工艺、检测方法以及临床应用情况进行了深入地总结和归纳,旨在为后续以巴戟天寡糖为主要成分的抗抑郁药物研究以及从中药和天然产物中发现抗抑郁药物的研发提供有益的借鉴和参考。Morinda officinalis is one of the four traditional southern medicines in China.Modern studies show that its oligosaccharides have good anti-depression activity.After continuous research and development by Chinese scientists,Morinda officinalis oligosaccharide Capsules,which are mainly composed of Morinda officinalis oligosaccharide,have been approved to be marketed as the fifth kinds of anti-depression new drugs in Chinese traditional medicine with independent intellectual property rights.By referring to the domestic and foreign literature on Morinda officinalis oligosaccharide as the research object,this paper comprehensively summarizes and combs the research and development process,anti-depression mechanism,extraction process,detection method and clinical application of Morinda officinalis oligosaccharide,which provides references for the subsequent research on Morinda officinalis oligosaccharides and the research and development of antidepressant drugs discovered from traditional Chinese medicine and natural products.

关 键 词：巴戟天寡糖 胶囊 抑郁症 临床应用 检测方法 

分 类 号：R282[医药卫生—中药学]