Nickel-Catalyzed Regio-and Stereoselective Defluorinative Arylation of gem-Difluorinated Cyclopropanes  

作　　者：Shutao Qi Yunkai Hua Liangkai Pan Junfeng Yang Junliang Zhang 

机构地区：[1]Department of Chemistry,Fudan University,2005 Songhu Road,Shanghai,200438 China [2]Fudan Zhangjiang Institute,Shanghai,201203 China [3]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan 453007,China

出　　处：《Chinese Journal of Chemistry》2024年第8期823-828,共6页中国化学（英文版）

基　　金：the funding support of the National Key R&D Program of China(2021YFF0701600);NSFC(21901043,21921003,and 22031004);STCSM(21ZR1445900)and Shanghai Municipal Education Commission(20212308).

摘　　要：Comprehensive Summary,Herein,we report nickel-catalyzed cross-coupling of gem-difluorinated cyclopropanes with boronic acids,providing the corresponding arylated 2-fluoroallylic scaffolds.This approach used commercially available phosphine ligand Xantphos to obtain monofluorinated alkenes with high regioselectivity and Z-stereoselectivity.Mechanistic studies proposed a Ni(II)-fluoroallyl pathway and excluded the radical pathway.

关 键 词：Nickel Monofluoroolefin CYCLOPROPANE Regioselectivity STEREOSELECTIVITY C-C coupling Cross-coupling Synthetic methods 

分 类 号：O62[理学—有机化学]