唾液酸结合免疫球蛋白样凝集素-15在食管鳞癌组织中的表达及意义  

Expression and significance of sialic acid-binding immunoglobulin-like lectin-15 in esophageal squamous cell carcinoma

作　　者：郑晓东[1] 张卫民[1] ZHENG Xiaodong;ZHANG Weimin(Department of Thoracic Surgery,Anyang Cancer Hospital,Anyang 455000,China)

机构地区：[1]安阳市肿瘤医院胸外科,河南安阳455000

出　　处：《肿瘤基础与临床》2024年第2期140-142,共3页journal of basic and clinical oncology

基　　金：河南省医学科技攻关计划(联合共建)项目(LHGJ20191286)。

摘　　要：目的探讨免疫检查点唾液酸结合免疫球蛋白样凝集素-15(Siglec-15)在食管鳞癌中的表达及意义。方法免疫组化检测食管鳞癌组织、癌旁正常食管组织中Siglec-15表达情况,并比较分析其与食管鳞癌患者临床病理特征的关系。结果Siglec-15在食管鳞癌组织中表达阳性率为60.0%(48/80),高于癌旁正常食管组织中的23.75%(19/80)(χ^(2)=21.595,P<0.001)。食管鳞癌组织中Siglec-15蛋白表达与患者肿瘤直径、T分期、TNM分期、N分期及分化程度有关(χ^(2)=7.500,P=0.006;χ^(2)=10.342,P=0.001;χ^(2)=22.547,P=0.016;χ^(2)=20.508,P<0.001;χ^(2)=12.586,P=0.002)。结论Siglec-15在食管鳞癌组织中高表达,与患者的疾病进展显著相关。Objective To investigate the expression and significance of immune checkpoint sialic acid-binding immunoglobulin-like lectin-15(Siglec-15)in esophageal squamous cell carcinoma.Methods Immunohistochemical method was used to detect Siglec-15 expression in esophageal cancer tissue and adjacent tissue,and the relationship between Siglec-15 and clinicopathologic characteristics of esophageal squamous cell carcinoma.Results The Siglec-15 protein positive in esophageal squamous cell carcinoma tissues[60.0%(48/80)]was higher than that in normal esophageal tissues adjacent to the cancer[23.75%(19/80);χ^(2)=21.595,P<0.001].There were statistical differences between Siglec-15 protein positivity and tumour diameter,T stage,TNM stage,N stage and degree of differentiation under different pathologies of esophageal squamous cell carcinoma(χ^(2)=7.500,P=0.006;χ^(2)=10.342,P=0.001;χ^(2)=22.547,P=0.016;χ^(2)=20.508,P<0.001;χ^(2)=12.586,P=0.002).Conclusion Siglec-15 is highly expressed in esophageal squamous cell carcinoma,and is related with disease progression.

关 键 词：免疫检查点 唾液酸结合免疫球蛋白样凝集素-15 食管鳞癌 

分 类 号：R735.1[医药卫生—肿瘤]