铁死亡对椎间盘变性的影响机制研究进展  

Research Progress on the Impact Mechanism of Ferroptosis on Intervertebral Disc Degeneration

作　　者：张彦军[1] 刘晏东 邓强[1] 郭铁峰[1] 李家明 檀盛 罗林钊 ZHANG Yanjun;LIU Yandong;DENG Qiang;GUO Tiefeng;LI Jiaming;TAN Sheng;LUO Linzhao(Spinal Orthopedics Department 2 of Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730000,China;Graduate School of Gansu University of Traditional Chinese Medicine,Lanzhou 730050,China)

机构地区：[1]甘肃省中医院脊柱骨二科,兰州730000 [2]甘肃中医药大学研究生院,兰州730050

出　　处：《中国细胞生物学学报》2024年第5期1021-1027,共7页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:82060879、82360947);甘肃省联合科研基金(批准号:23JRRA1534);甘肃省中医药科研课题(批准号:GZKZ-2022-1);甘肃省重点人才项目(批准号:2024-4);兰州市科技计划项目(批准号:2022-3-30)资助的课题。

摘　　要：椎间盘变性(intervertebral disc degeneration,IVDD)是一种脊柱退行性疾病,最常见的部位是腰椎和颈椎,表现为椎间盘组织内水分和蛋白质含量下降,导致椎间盘磨损、疼痛、失去弹性后发生易位变化并可引发多种脊柱疾病。学术界已经针对IVDD开展了许多研究,其中铁死亡是椎间盘变性过程中的关键机制之一。细胞通过胞内铁浓度和自噬通路来决定是否进一步大量积累铁离子。过量的铁会引发自由基活性增强,对细胞膜、蛋白质和其他细胞结构造成损伤,进而促进细胞死亡和组织破坏。目前,针对治疗IVDD的有效药物较少,但靶向铁死亡可能是治疗IVDD的一种新思路和新方法。该综述深入阐述铁死亡诱导IVDD的机制以及与其他因素之间的相互作用,并基于铁死亡探讨IVDD更有效的防治方案。IVDD(intervertebral disc degeneration)is a degenerative disease of the spine,most commonly found in the lumbar and cervical vertebrae.It is characterized by a decrease in water and protein content in the intervertebral disc tissue,leading to disc wear,pain,loss of elasticity,and displacement,which can cause various spinal diseases.The academic community has conducted many studies on IVDD,among which ferroptosis is one of the key mechanisms in the process of intervertebral disc degeneration.Cells determine whether to further accumulate large amounts of iron ions through intracellular iron concentration and autophagy pathways.Excessive iron can lead to increased free radical activity,causing damage to cell membranes,proteins,and other cellular structures,thereby promoting cell death and tissue destruction.At present,there are few effective drugs for treating IVDD,but targeting ferroptosis may be a new approach and method for treating IVDD.This review provides an in-depth explanation of the mechanism of iron death induced IVDD and its interactions with other factors,and explores more effective prevention and treatment strategies for IVDD based on iron death.

关 键 词：铁死亡 脊柱疾病 椎间盘变性 作用机制 

分 类 号：R681.53[医药卫生—骨科学]