微泡超声造影剂的研究与应用概况  

Research and Application of Microbubble Ultrasound Contrast Agents

作　　者：闫梦 何朝星 李凤 王岳恒[3] 向柏 邵娟[4] YAN Meng;HE Chaoxing;LI Feng;WANG Yueheng;XIANG Bai;SHAO Juan*(Dept.of Pharmaceutics,School of Pharmacy,Hebei Medical University,Shijiazhuang 050017;Dept.of Abdominal Ultrasound,Second Hospital of Hebei Medical University,Shijiazhuang 050017;Dept.of Cardiac Ultrasound,Second Hospital of Hebei Medical University,Shijiazhuang 050017;Dept.of Senile Disease,The Third Hospital of Hebei Medical University,Shijiazhuang 050017)

机构地区：[1]河北医科大学药学院药剂学教研室,河北石家庄050017 [2]河北医科大学第二医院腹部超声科,河北石家庄050017 [3]河北医科大学第二医院心脏超声科,河北石家庄050017 [4]河北医科大学第三医院老年病科,河北石家庄050017

出　　处：《中国医药工业杂志》2024年第5期629-636,共8页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金资助项目(81973251);河北省自然科学基金资助项目(H2019206445);河北省2021年度医学科学研究课题(20211108)。

摘　　要：由于超声成像具有非侵入性、相对简便、无电离辐射等特点,已被广泛用于各个领域。超声造影剂在超声成像中发挥着重要作用,通常由软壳或硬壳材料组成,尺寸从纳米到微米不等,功能从最初的成像诊断发展成诊断、治疗一体化模式。部分上市的超声造影剂(例如Levovist■、Optison■、Definity■和Sonovue■)已在欧洲、亚洲等地区用于临床超声检查。该综述重点介绍了微泡超声造影剂的研究进展及其临床应用,以期为新型超声造影剂的开发提供参考。Ultrasound imaging has been widely used in various fields due to its non-invasiveness,relative simplicity,and no ionizing radiation.Ultrasound contrast agents play an important role in ultrasound imaging,which are usually composed of soft or hard shell materials,with sizes ranging from nanometers to micrometers.And their functions have evolved from initial imaging diagnosis to the integrated mode of diagnosis and treatment.Some marketed ultrasound contrast agents,such as Levovist®,Optison®,Definity®and SonoVue®have been used in clinical ultrasound examinations in Europe,Asia and elsewhere.This review focuses on the research progress of microbubble ultrasound contrast agents and their clinical applications,in order to provide a reference for the development of new ultrasound contrast agents.

关 键 词：超声成像 超声造影剂 微泡 临床应用 

分 类 号：R445.1[医药卫生—影像医学与核医学] R981.9[医药卫生—诊断学]