IgA缺乏型过敏性输血反应及防治策略  

IgA deficiency allergic transfusion reaction and its prevention and treatment strategies

作　　者：莫秋红 刘学军 刘艺 李贤 MO Qiuhong;LIU Xuejun;LIU Yi;LI Xian(Nanning Blood Center,Nanning Institute of Transfusion Medicine,Nanning 530003,China)

机构地区：[1]南宁中心血站、南宁输血医学研究所,广西南宁530003

出　　处：《中国输血杂志》2024年第6期705-709,共5页Chinese Journal of Blood Transfusion

基　　金：广西卫健委自筹经费科研课题(Z20201430)。

摘　　要：IgA缺乏型过敏性输血反应(allergic transfusion reactions,ATRs)常发生于产生抗-IgA的IgA缺乏症患者,当这些患者输注含有IgA的血液产品时,可导致过敏性输血反应,严重者可致死。我们对IgA缺乏症(immunoglobulin A deficiency,IgAD)的临床表现及影响因素,以及IgA缺乏导致的过敏性输血反应发病机制、实验室检测和防治策略进行综述,从而提高医务工作者对IgA缺乏型过敏性输血反应的认识和防范意识。IgA deficiency allergic transfusion reaction often occurs in patients with anti-IgA.When blood products containing IgA are transfused into these patients,it may lead to severe allergic transfusion reactions,which can be fatal in severe cases.This review summarizes the clinical manifestations and influencing factors of immunoglobulin A deficiency(IgAD),as well as the pathogenesis,laboratory test and prevention strategies of allergic transfusion reactions caused by IgA deficiency,so as to enhance prevention awareness of IgA deficiency allergic transfusion reaction in medical staff.

关 键 词：IGA缺乏症 过敏性输血反应 抗-IgA 防治 

分 类 号：R457.1[医药卫生—治疗学] R392.8[医药卫生—临床医学]