红细胞在感染免疫中的作用研究进展  

Research progress on the role of red blood cells in infectious diseases

作　　者：肖玲[1,2] 田力 XIAO Ling;TIAN Li(Institute of Blood Transfusion,Chinese Academy of Medical Sciences&Peking Union Medical College,Key Laboratory of Transfusion Adverse Reactions,Chinese Academy of Medical Sciences,Chengdu 610052,China;Department of Blood Transfusion,Deyang People′s Hospital)

机构地区：[1]中国医学科学院北京协和医学院输血研究所、中国医学科学院输血不良反应研究重点实验室,四川成都610052 [2]德阳市人民医院输血科

出　　处：《中国输血杂志》2024年第6期710-715,共6页Chinese Journal of Blood Transfusion

基　　金：中国医学科学院医学与健康科技创新工程(2021-I2M-1-060)。

摘　　要：红细胞作为血液中数量最多的细胞,逐渐被发现不仅有运送氧气和二氧化碳的功能,还以多种途径参与机体免疫调节。近期有多项研究发现红细胞可通过TLR9在正常生理和感染状态下参与免疫调节,确定红细胞可通过表面的糖蛋白介导参与机体免疫应答,证实红细胞通过表面补体受体和结合细胞因子参与感染性疾病的进展和免疫调节。我们将总结红细胞通过以上几种分子在感染免疫应答中作用的研究进展,以增加对红细胞在感染免疫中作用的全面认识和理解。As the most abundant cells in blood,red blood cells have been gradually found to not only transport oxygen and carbon dioxide,but also participate in immune regulation in many ways.Recently,many studies have found that red blood cells participate in immune regulation under normal physiological and infectious conditions through TLR9,and confirmed that red blood cells can participate in immune response through surface glycoprotein,and confirmed that red blood cells participate in the progress and immune regulation of infectious diseases through surface complement receptors and binding cytokines.This paper summarizes the research progress of the role of red blood cells in infectious immune response through the above molecules,so as to increase the comprehensive understanding of the role of red blood cells in infectious immunity.

关 键 词：红细胞 感染免疫 

分 类 号：R331.141[医药卫生—人体生理学] R457.11[医药卫生—基础医学]