股动脉灌注治疗糖尿病周围神经病变的疗效观察  

Therapeutic effect of femoral artery infusion therapy on diabetic peripheral neuropathy

作　　者：曾竹青[1] 李晓波 樊小慧[1] ZENG Zhuqing;LI Xiaobo;FAN Xiaohui(Department of Endocrinology,the Fourth Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi,China)

机构地区：[1]南昌大学第四附属医院内分泌科,江西南昌3300061

出　　处：《中国现代医生》2024年第16期9-11,共3页China Modern Doctor

基　　金：江西省卫生健康委科技计划项目(202130546)。

摘　　要：目的 探讨股动脉灌注治疗糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)的疗效。方法 选取2021年10月至2022年6月南昌大学第四附属医院内分泌科住院治疗的DPN患者86例,根据随机数字表法将纳入患者分为观察组和对照组,每组各43例。对照组患者给予常规治疗,观察组患者给予微动脉灌注前列地尔和甲钴胺治疗。比较治疗前后两组患者的空腹血糖、自制问卷量表评分及振动感觉阈值(vibrating perception threshold,VPT)。结果 两组患者治疗前后的空腹血糖比较差异均无统计学意义(P>0.05)。治疗前,两组患者的自制问卷量表评分和VPT比较差异均无统计学意义(P>0.05);治疗后,观察组患者的自制问卷量表评分和VPT均显著低于对照组(P<0.05)。结论 股动脉灌注治疗可明显改善DPN患者的症状及体征,近期效果较好,是一种安全有效的方法,可在临床推广应用。Objective To investigate the efficacy of femoral artery infusion therapy in treatment of diabetic peripheral neuropathy(DPN).Methods A total of 86 DPN patients hospitalized in Department of Endocrinology of the Fourth Affiliated Hospital of Nanchang University from October 2021 to June 2022 were selected and divided into observation group and control group according to random number table method,with 43 cases in each group.The patients of control group was given conventional treatment,and the patients of observation group was given microarterial infusion of alprostadil and mecobalamin.Fasting blood glucose,scores of self-made questionnaire and vibrating perception threshold(VPT) of two groups were compared before and after treatment.Results There was no significant difference in fasting blood glucose between two groups before and after treatment(P>0.05).Before treatment,there were no significant differences in scores of self-made questionnaire and VPT between two groups(P>0.05).After treatment,scores of self-made questionnaire and VPT of patients in observation group were significantly lower than those in control group(P<0.05).Conclusion Femoral artery infusion therapy can obviously improve the symptoms and signs of DPN patients,and the recent effect is good,and it is a safe and effective method,which can be popularized in clinical practice.

关 键 词：糖尿病周围神经病变 股动脉灌注治疗 

分 类 号：R587.2[医药卫生—内分泌]