糖化血红蛋白变异指数与代谢综合征及其组分的相关性研究  

Study on relationship between hemoglobin glycation index and metabolic syndrome and its components

作　　者：赵雅丽 肖美霞 刘燕[1] 曾治平 施胜铭[1] ZHAO Yali;XIAO Meixia;LIU Yan;ZENG Zhiping;SHI Shengming(Department of General Medicine,the First People’s Hospital of Huzhou,Huzhou 313000,Zhejiang,China;Department of General Medicine,the First Affiliated Hospital of Gannan Medical University,Ganzhou,341000,Jiangxi,China;Gannan sub-center,National Center for Clinical Research of Geriatric Diseases,Ganzhou,341000,Jiangxi,China)

机构地区：[1]湖州市第一人民医院全科医学科,浙江湖州313000 [2]赣南医科大学第一附属医院全科医学科,江西赣州341000 [3]国家老年疾病临床医学研究中心赣南分中心,江西赣州341000

出　　处：《中国现代医生》2024年第16期61-65,共5页China Modern Doctor

摘　　要：目的 探讨糖化血红蛋白变异指数(hemoglobin glycation index,HGI)与代谢综合征(metabolic syndrome,MS)及其组分的关系。方法 采用横断面研究,随机抽取2022年9月至2023年9月于湖州市第一人民医院就诊的患者823例,根据空腹血糖(fasting blood glucose,FPG)和糖化血红蛋白(glycosylated hemoglobin,HbA1c)数值计算HGI,采用HGI三分位数法将患者分为低HGI组(HGI<–0.250%,274例)、中HGI组(–0.250%≤HGI≤0.214%,275例)和高HGI组(HGI>0.214%,274例),比较各组患者的一般资料和代谢指标,HGI与MS及其各组分的相关性采用多元Logistic回归分析。结果 随着HGI水平的升高,MS患病率呈上升趋势(P<0.05),低、中、高HGI组患者的MS患病率分别为24.8%、42.5%、55.5%。多元Logistic回归分析结果显示,HGI水平升高是发生MS、中心性肥胖、高血压、高血糖、高三酰甘油血症、低高密度脂蛋白胆固醇血症的危险因素(P<0.05),高HGI组患者发生MS、中心性肥胖、高血压、高血糖、高三酰甘油血症、低高密度脂蛋白胆固醇血症的风险分别为低HGI组的4.005倍(95%CI:2.763~5.808)、3.765倍(95%CI:2.604~5.443)、1.596倍(95%CI:1.089~2.337)、2.655倍(95%CI:1.809~3.895)、2.024倍(95%CI:1.404~2.918)、2.247倍(95%CI:1.537~3.284)。结论 HGI与MS及其组分相关,HGI可能是预防和监测MS的新指标。Objective To investigate the relationship between hemoglobin glycation index(HGI) and metabolic syndrome(MS) and its components.Methods A cross-sectional study was conducted to randomly select 823 patients from the First People's Hospital of Huzhou from September 2022 to September 2023.HGI is calculated based on fasting blood glucose(FPG) and glycosylated hemoglobin(HbA1c) values.The patients were divided into low HGI group(HGI < –0.250%,274 cases),medium HGI group(–0.250%≤HGI≤0.214%,275 cases) and high HGI group(HGI > 0.214%,274 cases) by HGI quantile method.The general data and metabolic indexes of each group were compared,and the correlation between HGI and MS and its components was analyzed by multiple Logistic regression.Results With the increase of HGI level,the prevalence rate of MS showed an upward trend(P<0.05).The prevalence rate of MS in low,medium and high HGI groups was 24.8%,42.5% and 55.5%,respectively.Multiple Logistic regression analysis showed that elevated HGI level was risk factor for MS,central obesity,hypertension,hyperglycemia,hypertriglyceridemia and low high-density lipoprotein hyperlipidemia(P<0.05).The risk of MS,central obesity,hypertension,hyperglycemia,hypertriglyceridemia and low high-density lipoprotein hyperlipidemia in high HGI group was 4.005 times(95%CI:2.763-5.808),3.765 times(95%CI:2.604-5.443),1.596 times(95%CI:1.089-2.337),2.655 times(95%CI:1.809-3.895),2.024 times(95%CI:1.404-2.918) and 2.247 times(95%CI:1.537-3.284) of that in low HGI group,respectively.Conclusion HGI is related to MS and its components,and HGI may be a new indicator to prevent and monitor MS.

关 键 词：代谢综合征 糖化血红蛋白 糖基化 糖化血红蛋白变异指数 

分 类 号：R589[医药卫生—内分泌]