中药协定方治疗AECOPD患者的临床疗效及实验室指标观察  

Observation of clinical efficacy and laboratory indexes of traditional Chinese medicine in treating patients with AECOPD

作　　者：肖强 宋文名[2] 梅牧[1] 董素素 谭亚芬 张旋 姚璐 王天立[1] XIAO Qiang;SONG Wenming;MEI Mu;DONG Susu;TAN Yafen;ZHANG Xuan;YAO Lu;WANG Tianli(Department of Respiratory and Critical Care Medicine,the First People’s Hospital of Changde,Changde 415003,Hunan,China;Department of Integrated Chinese and Western Medicine,the First People’s Hospital of Changde,Changde 415003,Hunan,China)

机构地区：[1]常德市第一人民医院呼吸与危重症医学科,湖南常德415003 [2]常德市第一人民医院中西医结合科,湖南常德4150031

出　　处：《中国现代医生》2024年第16期85-89,共5页China Modern Doctor

基　　金：湖南省卫生健康委一般指导项目(202203022831)。

摘　　要：目的 评估中药痰浊阻肺协定方对慢性阻塞性肺疾病急性加重期(acute exacerbation of chronic obstructive pulmonary disease,AECOPD)患者的临床疗效及对实验室指标的影响。方法 选取2021年1月至2022年12月于常德市第一人民医院住院治疗的AECOPD患者191例,根据患者治疗意愿将其分为观察组(96例)和对照组(95例)。对照组患者接受常规西医治疗方案,观察组患者在此基础上口服本院中药痰浊阻肺协定方,疗程1周。比较两组患者的中医证候积分、慢性阻塞性肺病评估测试(COPD assessment test,CAT)、肺功能、实验室指标和疗效。结果 观察组患者的总有效率显著高于对照组(χ^(2)=4.573,P=0.030)。治疗后,两组患者的中医证候积分、CAT评分、超敏C反应蛋白(hypersensitive C-reaction protein,hsCRP)、白细胞介素-6(interleukin-6,IL-6)均显著低于本组治疗前,用力肺活量占预计值百分比(percentage of forced vital capacity to predicted value,FVC%)、第1秒用力呼气容积占预计值百分比(percentage of forced expiratory volume in one second to predicted value,FEV_(1)%)均显著高于本组治疗前(P<0.05);观察组患者的动脉血二氧化碳分压(arterial partial pressure of carbon dioxide,PaCO_(2))低于本组治疗前,动脉血氧分压(arterial partial pressure of oxygen,PaO_(2))高于本组治疗前(P<0.05);观察组患者的中医证候积分、CAT评分、hsCRP、IL-6均显著低于对照组,FVC%、FEV_(1)%、PaO_(2)均显著高于对照组(P<0.05)。结论 在西医治疗基础上辅以痰浊阻肺协定方可更有效改善AECOPD患者的临床症状,缓解体内炎症,有助于肺功能恢复,提高患者的生活质量。Objective To evaluate the clinical efficacy of traditional Chinese medicine turbid phlegm obstructing lung decoction on patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) and its influence on laboratory indexes.Methods A total of 191 patients with AECOPD who were hospitalized in the First People's Hospital of Changde from January 2021 to December 2022 were selected.Patients were divided into observation group(96 cases) and control group(95 cases) according to their treatment intention.The control group received conventional treatment of western medicine,and the observation group received oral administration of traditional Chinese medicine turbid phlegm obstructing lung decoction for one week.TCM symptom scores,COPD assessment test(CAT),lung function,laboratory indicators and efficacy were compared between two groups.Results The total effective rate of observation group was significantly higher than that of control group(χ^(2)=4.573,P=0.030).After treatment,TCM symptom score,CAT score,hypersensitive C-reaction protein(hsCRP) and interleukin-6(IL-6) of patients in both groups were significantly lower than before treatment,percentage of forced vital capacity to predicted value(FVC%) and percentage of forced expiratory volume in one second to predicted value(FEV_(1)%) were significantly higher than before treatment(P<0.05),arterial partial pressure of carbon dioxide(PaCO_(2)) of observation group was lower than before treatment,and arterial partial pressure of oxygen(PaO_(2)) was higher than before treatment(P<0.05).The TCM symptom score,CAT score,hsCRP and IL-6 of observation group were significantly lower than those of control group,while FVC%,FEV_(1)% and PaO_(2) were significantly higher than those of control group(P<0.05).Conclusion On the basis of western medicine treatment,traditional Chinese medicine turbid phlegm obstructing lung decoction can more effectively improve clinical symptoms of AECOPD patients,relieve the inflammation in the body,contribute to the recovery of lung f

关 键 词：痰浊阻肺协定方 慢性阻塞性肺疾病急性加重期 中医药疗法 

分 类 号：R563[医药卫生—呼吸系统] R256.1[医药卫生—内科学]