银杏蜜环口服溶液治疗冠心病合并抑郁的临床效果及对免疫功能的影响  

Clinical effect of ginkgo leaf extract and armillariella mellea powders oral solution on the treatment of coronary heart disease combined with depression and its impact on immune function

作　　者：苏雯雯 蒋健刚[1,3] SU Wenwen;JIANG Jiangang(Graduate School,Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang,China;Department of Internal Medicine,Cixi Seventh People’s Hospital,Cixi 315300,Zhejiang,China;Department of Cardiology,Jinhua Hospital of Traditional Chinese Medicine,Jinhua 321017,Zhejiang,China)

机构地区：[1]浙江中医药大学研究生院,浙江杭州310053 [2]慈溪市第七人民医院内科,浙江慈溪315300 [3]金华市中医医院心内科,浙江金华321017

出　　处：《中国现代医生》2024年第16期90-93,97,共5页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2021ZB317);浙江省医药卫生科技项目(2022KY1337);浙江中医药大学附属医院科研专项(2022A090)。

摘　　要：目的 探讨银杏蜜环口服溶液治疗冠心病合并抑郁的临床效果及对免疫功能的影响。方法 选取2019年7月至2023年7月金华市中医医院和慈溪市第七人民医院收治的冠心病合并抑郁患者124例,随机将其分为对照组和观察组,每组各62例。对照组患者采用常规方案治疗,观察组患者在此基础上增加银杏蜜环口服溶液治疗。经8周治疗后,比较两组患者的炎症因子、免疫功能、生活质量及抑郁评分。结果 治疗后,两组患者的C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-8(interleukin-8,IL-8)、CD8^(+)水平均显著低于本组治疗前,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均显著高于本组治疗前(P<0.05);观察组患者的CRP、TNF-α、IL-8、CD8^(+)水平均显著低于对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)均显著高于对照组(P<0.05)。治疗后,两组患者的西雅图心绞痛量表(Seattle angina questionnair,SAQ)各维度评分均显著高于本组治疗前(P<0.05),观察组患者的SAQ各维度评分均显著高于对照组(P<0.05)。治疗后,观察组患者的汉密尔顿抑郁量表评分显著低于对照组[(9.26±1.58)分vs.(12.87±1.89)分,t=11.538,P<0.001]。结论 银杏蜜环口服溶液可抑制冠心病合并抑郁患者的炎症反应并改善其抑郁症状,提高患者的免疫功能和生活质量。Objective To investigate the clinical effect of ginkgo leaf extract and armillariella mellea powders oral solution on the treatment of coronary heart disease complicated with depression and its impact on immune function.Methods A total of 124 patients with coronary heart disease combined with depression admitted to Jinhua Hospital of Traditional Chinese Medicine and Cixi Seventh People's Hospital from July 2019 to July 2023 were randomly divided into control group and observation group,with 62 cases in each group.The control group received conventional treatment,while the observation group received additional treatment with ginkgo leaf extract and armillariella mellea powders oral solution on this basis.After 8 weeks of treatment,inflammatory factors,immune function,quality of life and depression scores were compared between two groups.Results After treatment,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-8(IL-8) and CD8^(+) in two groups were significantly lower than before treatment,while the levels of CD3^(+),CD4^(+) and CD4^(+)/CD8^(+) were significantly higher than before treatment(P<0.05).The levels of CRP,TNF-α,IL-8 and CD8^(+) in observation group were significantly lower than those in control group,while the levels of CD3^(+),CD4^(+) and CD4^(+)/CD8^(+) were significantly higher than those in control group(P<0.05).After treatment,the scores of Seattle angina questionnair(SAQ) in all dimensions in both groups were significantly higher than before treatment(P<0.05),and the scores of SAQ in all dimensions in observation group were significantly higher than those in control group(P<0.05).After treatment,the Hamilton depression scale score of observation group was significantly lower than that of control group [(9.26±1.58) points vs.(12.87±1.89) points,t=11.538,P<0.001].Conclusion Ginkgo leaf extract and armillariella mellea powders oral solution can inhibit the inflammatory response and improve the symptoms of depression in patients with coronary heart disease and impro

关 键 词：冠心病 抑郁 银杏蜜环口服溶液 免疫功能 炎症反应 

分 类 号：R541.4[医药卫生—心血管疾病] R749.4[医药卫生—内科学]