白癜风同形反应相关因素的多变量分析:一项针对217例患者的观察性研究  

Multivariate analysis of factors associated with koebner phenomenon to vitiligo:An observational study of 217 patients

作　　者：曾悦[1] 邢荣贵 刘付华 程雪 高琰 陈锦纯 李思 吴逸凡 邹先彪 Zeng Yue;Xing Ronggui;Liu Fuhua;Cheng Xue;Gao Yan;Chen Jinchun;Li Si;Wu Yifan;Zou Xianbiao(Department of Dermatovenerology&Medical Cosmetology,South China Hospital Affiliated to Shenzhen University,Shenzhen 518061,Guangdong,China)

机构地区：[1]深圳大学附属华南医院皮肤性病与医学美容科,深圳518061

出　　处：《中国医学前沿杂志（电子版）》2024年第5期6-11,共6页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

摘　　要：目的研究白癜风中与同形反应(koebner phenomenon,KP)相关的因素。方法收集自2021年11月21日至2024年2月7日于深圳大学附属华南医院皮肤性病与医学美容科门诊就诊的217例白癜风患者信息,进行观察性研究。临床信息通过患者完成白癜风欧洲工作组问卷和临床检查获得。从中提取相关信息进行多因素分析以评估白癜风临床特征与KP的相关性。结果217例白癜风患者中男性123例(56.68%),女性94例(43.31%),平均就诊(29.17±15.56)岁,平均发病(25.85±14.86)岁,病程为24(6,72)个月。KP阳性病例116例,KP阴性病例101例。与KP阴性病例相比,KP阳性病例的年龄(P=0.002)、病程(P=0.007)、白斑数量(P<0.001)、体表面积(P=0.024)、甲状腺结节(P=0.001)和体表面积(body surface area,BSA)%(P<0.001)显著增加。白癜风分型中,节段型白癜风(44例,43.56%)和未定类型白癜风(35例,34.65%)常见KP阴性患者,而非节段型白癜风(26例,22.41%)和混合型白癜风(68例,58.62%)在KP阳性患者中更常见(P<0.001)。疾病活动度(OR=3.598),病程(OR=1.006),年龄(OR=1.060),BSA(OR=3.921)和白斑数量(OR=3.901)与KP显著相关。结论KP对预测白癜风的进展期和临床病程具有一定的意义。Objective To investigate the factors related to koebner phenomenon(KP)of vitiligo.Methods An observational study was conducted on 217 patients with vitiligo who visited the outpatient Department of Dermatovenerology&Medical Cosmetology of South China Hospital Affiliated to Shenzhen University from November 21,2021 to February 7,2024.Clinical information was obtained by completing the Vitiligo European Task Force(VETF)questionnaire and clinical examination.The relevant information was extracted and multifactor analysis was performed to evaluate the correlation with KP.Results A total of 217 patients with vitiligo were included in this study,including 123 males(56.68%)and 94 females(43.31%).The mean age of treatment was(29.17±15.56)years,the mean age of onset was(25.85±14.86)years,and the median duration of disease was 24(6,72)months.There were 116 cases showed are KP positive and other cases showed are KP negative.The age(P=0.002),duration of disease(P=0.007),number of white spots(P<0.001),body surface area(P=0.024),thyroid nodule(P=0.001)and BSA%(P<0.001)in KP-positive cases significantly increased compared with KP-negative cases(P<0.001).Among vitiligo types,segmental vitiligo(44 cases,43.56%)and unclassifiable types vitiligo(35 cases,34.65%)were more common in KP negative patients,while non-segmental vitiligo(26 cases,22.41%)and mixed vitiligo(68 cases,58.62%)were more common in KP patients(P<0.001).Disease activity(OR=3.598),course of disease(OR=1.006),age(OR=1.060),body surface area(OR=3.921)and number of white spots(OR=3.901)were significantly correlated with KP.Conclusions KP has a certain significance in predicting the progression and clinical course of the disease.

关 键 词：白癜风 同形反应 观察性研究 

分 类 号：R75[医药卫生—皮肤病学与性病学]