新诊断2型糖尿病合并非酒精性脂肪肝发生的影响因素分析  

Analysis of influencing factors of newly diagnosed type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease

作　　者：陈国兰[1] 林延艳 何炎青 覃小静 CHEN Guolan;LIN Yanyan;HE Yanqing;QIN Xiaojing(Endocrinology Department,Liuzhou People's Hospital,Liuzhou 545006,China)

机构地区：[1]柳州市人民医院内分泌科,广西柳州545006

出　　处：《临床医学研究与实践》2024年第18期1-4,共4页Clinical Research and Practice

基　　金：广西壮族自治区卫生健康委员会自筹经费科研课题(No.Z20190030)。

摘　　要：目的分析新诊断2型糖尿病(T2DM)合并非酒精性脂肪性肝病(NAFLD)发生的影响因素。方法收集2019至2020年在我院内分泌科住院的166例新诊断为T2DM患者作为研究对象,根据腹部B超检查结果,参照相关诊断标准将其分为T2DM合并NAFLD组(113例)和单纯T2DM组(53例)。收集所有患者的一般资料,包括性别、年龄、体重、体质指数(BMI)、收缩压(SBP)及舒张压(DBP);检测两组患者的生化指标,包括糖化血红蛋白(HbA1c)、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)水平。采用多因素Logistic回归分析探讨T2DM合并NAFLD发生的影响因素。结果两组患者的年龄、SBP及DBP比较,差异无统计学意义(P>0.05);两组患者的性别比较,差异具有统计学意义(P<0.05);T2DM合并NAFLD组的体重、BMI大于单纯T2DM组,差异具有统计学意义(P<0.05)。两组患者的FBG、TC及HDL-C水平比较,差异无统计学意义(P>0.05);T2DM合并NAFLD组的HbA1c、LDL-C水平低于单纯T2DM组,差异具有统计学意义(P<0.05);T2DM组合并NAFLD组的TG水平高于单纯T2DM组(P<0.05)。多因素Logistic回归分析结果显示,性别、体重、HbA1c及TG是T2DM合并NAFLD发生的影响因素(P<0.05)。结论性别、体重、HbA1c及TG是新诊断T2DM合并NAFLD发生的影响因素,临床应针对女性、肥胖、低HbA1c及高TG水平患者开展筛查,进一步预防及干预T2NM合并NAFLD发生,并针对影响因素开展相关措施。Objective To analyze the influencing factors of newly diagnosed type 2 diabetes mellitus(T2DM)complicated with non-alcoholic fatty liver disease(NAFLD).Methods A total of 166 newly diagnosed T2DM patients who were hospitalized in the endocrinology department of our hospital from 2019 to 2020 were selected as the research objects.According to the results of abdominal B-ultrasound examination and the relevant diagnostic criteria,the patients were divided into T2DM complicated with NAFLD group(113 cases)and simple T2DM group(53 cases).The general data of all patients were collected,including gender,age,weight,body mass index(BMI),systolic blood pressure(SBP)and diastolic blood pressure(DBP);the biochemical indexes of the two groups were detected,including glycosylated hemoglobin(HbA1c),fasting blood glucose(FBG),total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)levels.Multivariate Logistic regression analysis was used to explore the influencing factors of T2DM complicated with NAFLD.Results There were no significant differences in age,SBP and DBP between the two groups of patients(P>0.05);there was significant difference in gender between the two groups of patients(P<0.05);the body weight and BMI of the T2DM complicated with NAFLD group were higher than those of the simple T2DM group,and the differences were statistically significant(P<0.05).There were no significant differences in FBG,TC and HDL-C levels between the two groups of patients(P>0.05);the levels of HbA1c and LDL-C in the T2DM complicated with NAFLD group were lower than those in the simple T2DM group,and the differences were statistically significant(P<0.05);the level of TG in the T2DM complicated with NAFLD group was higher than that in the simple T2DM group(P<0.05).Multivariate Logistic regression analysis results showed that gender,weight,HbAlc and TG were the influencing factors for T2DM complicated with NAFLD(P<0.05).Conclusion Gender,weight,HbAlc and TG are influencing f

关 键 词：2型糖尿病 非酒精性脂肪性肝病 体重 甘油三酯 

分 类 号：R587.1[医药卫生—内分泌] R575.5[医药卫生—内科学]