TyG指数与冠状动脉钙化的关系研究  

Study on the relationship between TyG index and coronary artery calcification

作　　者：王培育 金富璐 王莉[2] 蒋雨枫 曾钇尧 常先松 赵良平[1,3] WANG Peiyu;JIN Fulu;WANG Li;JIANG Yufeng;ZENG Yiyao;CHANG Xiansong;ZHAO Liangping(Cardiology Department,the Second Affiliated Hospital of Soochow University,Suzhou 215004;Emergency Department,Xuguan District of the Second Affiliated Hospital of Soochow University,Suzhou 215151;Cardiology Department,the Fourth Affiliated Hospital of Soochow University,Suzhou 215000,China)

机构地区：[1]苏州大学附属第二医院心内科,江苏苏州215004 [2]苏州大学附属第二医院浒关院区急诊科,江苏苏州215151 [3]苏州大学附属第四医院心内科,江苏苏州215000

出　　处：《临床医学研究与实践》2024年第18期5-8,共4页Clinical Research and Practice

基　　金：苏州市科技计划项目(No.SLJ2022007);2023年度苏州市基础研究计划(医学应用基础研究)项目(No.SKYD2023084)。

摘　　要：目的探究甘油三脂-葡萄糖(TyG)指数与冠状动脉钙化(CAC)的关系。方法回顾性纳入1572例经冠状动脉计算机断层扫描血管造影(CTA)检查患者为研究对象,根据冠脉钙化积分(CACS)将其分为钙化组(CACS≥1分)和无钙化组(CACS=0分)。采用多因素Logistic回归分析评估CAC发生的影响因素。结果1572例患者中,存在CAC的患者808例(钙化组);无CAC的患者764例(无钙化组)。钙化组的男性占比、年龄、高血压史占比、糖尿病史占比、TyG指数、空腹血糖、糖化血红蛋白、血尿素氮、血肌酐、C反应蛋白水平高于无钙化组(P<0.05)。Logistic回归分析显示,年龄、高血压史、糖尿病史、TyG指数、血肌酐、C-反应蛋白是CAC发生的独立危险因素(P<0.05)。结论TyG指数与CAC的发生独立相关,其对CAC的发生有较高预测价值。Objective To investigate the relationship between triglyceride-glucose(TyG)index and coronary artery calcification(CAC).Methods A total of 1572 patients who underwent coronary computed tomography angiography(CTA)examination were retrospectively included in the study.According to the coronary artery calcium score(CACS),the patients were divided into calcification group(CACS≥1)and non-calcification group(CACS=0).Multivariate Logistic regression analysis was used to evaluate the influencing factors of CAC.Results Among the 1572 patients,there were 808 patients with CAC(calcification group);there were 764 patients without CAC(non-calcification group).The proportion of males,age,proportion of hypertension history,proportion of diabetes history,TyG index,fasting blood glucose,glycosylated hemoglobin,blood urea nitrogen,serum creatinine and C-reactive protein levels in the calcification group were higher than those in the non-calcification group(P<0.05).Logistic regression analysis showed that age,hypertension history,diabetes history,TyG index,serum creatinine and C-reactive protein were independent risk factors for CAC(P<0.05).Conclusion TyG index is independently associated with the occurrence of CAC,which has a high predictive value for the occurrence of CAC.

关 键 词：冠状动脉钙化 甘油三脂-葡萄糖指数 胰岛素抵抗 

分 类 号：R543.3[医药卫生—心血管疾病]