固肾安胎丸联合低分子肝素、小剂量阿司匹林对复发性流产患者血栓前状态及Th17/Treg的影响  

Effects of Gushen Antai pills combined with low molecular weight heparin and low-dose aspirin on prethrombotic state and Th17/Treg in patients with recurrent abortion

作　　者：郭一卜 黄向红 孙金线 GUO Yibo;HUANG Xianghong;SUN Jinxian(Gynecology and Obstetrics Department,Xijing Hospital 986 Hospital,Xi'an 710054;No.1 Obstetrics Department,Xianyang Rainbow Hospital,Xianyang 712000,China)

机构地区：[1]西京医院九八六医院妇产科,陕西西安710054 [2]咸阳彩虹医院产一科,陕西咸阳712000

出　　处：《临床医学研究与实践》2024年第18期102-105,共4页Clinical Research and Practice

摘　　要：目的探讨固肾安胎丸联合低分子肝素、小剂量阿司匹林对复发性流产患者血栓前状态及辅助性T细胞17(Th17)/调节性T细胞(Treg)的影响。方法择取2021年6月至2022年6月就诊的80例复发性流产患者为研究对象,随机将其分为对照组和观察组,各40例。对照组给予低分子肝素、小剂量阿司匹林治疗,观察组在对照组基础上加固肾安胎丸治疗。比较两组的治疗效果。结果治疗后,观察组的蛋白C(PC)、蛋白S(PS)及抗凝血酶Ⅲ(AT-Ⅲ)高于对照组,D-二聚体(D-D)水平低于对照组(P<0.05)。治疗后,观察组的Th17、Th17/Treg低于对照组,Treg高于对照组(P<0.05)。观察组的不良反应总发生率低于对照组(P<0.05)。结论固肾安胎丸联合低分子肝素、小剂量阿司匹林不仅能够调节复发性流产患者的血栓前状态,还能改善Th17/Treg指标,且不良反应较少。Objective To investigate the effects of Gushen Antai pills combined with low molecular weight heparin and low-dose aspirin on prethrombotic state and helper T cell 17(Th17)/regulatory T cell(Treg)in patients with recurrent abortion.Methods A total of 80 patients with recurrent abortion who were admitted from June 2021 to June 2022 were selected as the study objects,and randomly divided into control group and observation group,with 40 cases in each group.The control group was treated with low molecular weight heparin and low-dose aspirin,and the observation group was treated with Gushen Antai pills on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the protein C(PC),protein S(PS)and antithrombin-Ⅲ(AT-Ⅲ)in the observation group were higher than those in the control group,and the level of D-dimer(D-D)was lower than that in the control group(P<0.05).After treatment,the Th17 and Th17/Treg in the observation group were lower than those in the control group,and the Treg was higher than that in the control group(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Conclusion Gushen Antai pills combined with low molecular weight heparin and low-dose aspirin can not only regulate the prethrombotic state of patients with recurrent abortion,but also improve the Th17/Treg index,with fewer adverse reactions.

关 键 词：固肾安胎丸 低分子肝素 小剂量阿司匹林 复发性流产 血栓前状态 辅助性T细胞17 调节性T细胞 

分 类 号：R285.6[医药卫生—中药学]